Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLCN2 | P51788 | 5/20 | 0.50 |
| ▸ | CLIC1 | O00299 | 1/20 | 0.50 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.47 |
| ▸ | METTL3 | Q86U44 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | FABP2 | P12104 | 1/20 | 0.47 |
| ▸ | RXRA | P19793 | 1/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11350088 | 0.87 | CLCN2 (0.48) | CLCN2CLIC1CXCL8PTGS2METTL3 | |
| SCHEMBL11343262 | 0.84 | PTGS2 (0.52) | CXCL8PTGS2AKR1B10ABCB11TTR | |
| SCHEMBL11340774 | 0.84 | CLCN2 (0.69) | CLCN2CLIC1CXCL8PTGS2METTL3 | |
| SCHEMBL11346825 | 0.82 | CLCN2 (0.44) | CLCN2CLIC1CXCL8PTGS2METTL3 | |
| SCHEMBL11350661 | 0.80 | PTGS2 (0.45) | CXCL8PTGS2MAPK1KMT2AAKR1B10 | |
| SCHEMBL8352685 | 0.79 | CLCN2 (0.71) | CLCN2CLIC1CXCL8PTGS2METTL3 | |
| SCHEMBL11346663 | 0.78 | P2RX7 (0.37) | CLCN2CLIC1CXCL8PTGS2LMNA | |
| SCHEMBL11348145 | 0.77 | PTGS2 (0.45) | PTGS2LMNACYP3A4MAPTTSHR | |
| SCHEMBL11378085 | 0.74 | PTGS2 (0.68) | CLCN2CLIC1CXCL8PTGS2METTL3 | |
| SCHEMBL11342484 | 0.72 | MT-CO2 (0.48) | PTGS2MEN1KMT2ATTRADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0005559-B1 | PHENYLAMINOTHIOPHENE ACETIC ACIDS, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1981-11-04 | — | — | EP | disclosed |
| US-4272507-A | Phenylaminothiophenacetic acids, their synthesis, compositions and use | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1981-06-09 | — | — | US | disclosed |
| EP-0005559-A1 | Phenylaminothiophene acetic acids, process for their preparation and medicaments containing them | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1979-11-28 | — | — | EP | disclosed |