Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.52 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.41 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.38 |
| ▸ | UGT1A9 | O60656 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | ALB | P02768 | 1/20 | 0.38 |
| ▸ | UGT1A6 | P19224 | 1/20 | 0.38 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.38 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.38 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.38 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11348145 | 0.91 | PTGS2 (0.45) | PTGS2RAPGEF4CYP3A4TSHRBLM | |
| SCHEMBL11350661 | 0.91 | PTGS2 (0.45) | PTGS2CXCL8GAAPTGS1AKR1B10 | |
| SCHEMBL11351958 | 0.87 | PTGS2 (0.50) | PTGS2RAPGEF4CXCL8GAAMAPK14 | |
| SCHEMBL11345544 | 0.84 | CLCN2 (0.50) | PTGS2CXCL8GAAPTGS1AKR1B10 | |
| SCHEMBL8956861 | 0.83 | PTGS2 (0.72) | PTGS2CXCL8PTGS1AKR1B10UGT1A9 | |
| SCHEMBL11342484 | 0.82 | MT-CO2 (0.48) | PTGS2RAPGEF4MT-CO2TTRADRA1A | |
| SCHEMBL11346663 | 0.82 | P2RX7 (0.37) | PTGS2RAPGEF4CXCL8 | |
| SCHEMBL11351522 | 0.82 | PTGS2 (0.46) | PTGS2RAPGEF4CXCL8GAALCK | |
| SCHEMBL11369085 | 0.81 | PTGS2 (0.55) | PTGS2CXCL8GAAMAPK14PTGS1 | |
| SCHEMBL11354733 | 0.78 | CXCL8 (0.47) | CXCL8GAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0005559-B1 | PHENYLAMINOTHIOPHENE ACETIC ACIDS, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1981-11-04 | — | — | EP | disclosed |
| US-4272507-A | Phenylaminothiophenacetic acids, their synthesis, compositions and use | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1981-06-09 | — | — | US | disclosed |
| EP-0005559-A1 | Phenylaminothiophene acetic acids, process for their preparation and medicaments containing them | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1979-11-28 | — | — | EP | disclosed |