Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.45 |
| ▸ | RAPGEF4 | Q8WZA2 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11343262 | 0.91 | PTGS2 (0.52) | PTGS2RAPGEF4CYP3A4TSHRBLM | |
| SCHEMBL11347701 | 0.83 | PTGS2 (0.42) | PTGS2RAPGEF4LMNACYP3A4CYP2D6 | |
| SCHEMBL11353757 | 0.81 | PTGS2 (0.67) | PTGS2MAPT | |
| SCHEMBL11346663 | 0.81 | P2RX7 (0.37) | PTGS2RAPGEF4LMNARAB9APDCD1 | |
| SCHEMBL11350661 | 0.80 | PTGS2 (0.45) | PTGS2LMNACYP3A4TSHRBLM | |
| SCHEMBL11351373 | 0.80 | PTGS2 (0.36) | PTGS2 | |
| SCHEMBL11354463 | 0.80 | PTGS2 (0.39) | PTGS2RAPGEF4LMNACYP3A4CYP2D6 | |
| SCHEMBL11345544 | 0.77 | CLCN2 (0.50) | PTGS2LMNACYP3A4TSHRMAPT | |
| SCHEMBL11351958 | 0.76 | PTGS2 (0.50) | PTGS2RAPGEF4CYP3A4TSHRBLM | |
| SCHEMBL11342484 | 0.75 | MT-CO2 (0.48) | PTGS2RAPGEF4LMNACYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0005559-B1 | PHENYLAMINOTHIOPHENE ACETIC ACIDS, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1981-11-04 | — | — | EP | disclosed |
| US-4272507-A | Phenylaminothiophenacetic acids, their synthesis, compositions and use | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1981-06-09 | — | — | US | disclosed |
| EP-0005559-A1 | Phenylaminothiophene acetic acids, process for their preparation and medicaments containing them | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1979-11-28 | — | — | EP | disclosed |