Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RBP4 | P02753 | 1/20 | 0.41 |
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SPR | P35270 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.37 |
| ▸ | TNKS | O95271 | 1/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11251854 | 0.85 | RBP4 (0.41) | RBP4ADAMTS5ESR1PARP1SPR | |
| SCHEMBL11247593 | 0.83 | SIGMAR1 (0.48) | PARP1PARP2 | |
| SCHEMBL11334889 | 0.83 | ALDH1A1 (0.48) | RBP4ADAMTS5ESR1ALDH1A1PARP1 | |
| SCHEMBL11344269 | 0.78 | ALDH1A1 (0.44) | ADAMTS5ESR1ALDH1A1PARP1SMN1; SMN2 | |
| SCHEMBL11354008 | 0.78 | ALDH1A1 (0.47) | ADAMTS5ESR1ALDH1A1PARP1SMN1; SMN2 | |
| SCHEMBL11348088 | 0.78 | SPR (0.47) | ADAMTS5ESR1ALDH1A1PARP1SMN1; SMN2 | |
| SCHEMBL11343261 | 0.76 | ALDH1A1 (0.45) | ADAMTS5ESR1ALDH1A1PARP1SMN1; SMN2 | |
| SCHEMBL11331493 | 0.75 | ALDH1A1 (0.53) | ESR1ALDH1A1PARP1SMN1; SMN2LMNA | |
| SCHEMBL11346625 | 0.75 | ALDH1A1 (0.45) | ADAMTS5ESR1ALDH1A1PARP1SPR | |
| SCHEMBL11233209 | 0.74 | ALDH1A1 (0.71) | ESR1ALDH1A1PARP1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4251538-A | Indolealkylamines and processes for their preparation | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-02-17 | — | — | US | disclosed |
| EP-0007399-A1 | Indolylalkyl amines, pharmaceutical preparations containing them and process for their manufacture | MERCK PATENT GmbH (DE) | 1980-02-06 | — | — | EP | disclosed |