Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | RBP4 | P02753 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11352649 | 0.85 | ALDH1A1 (0.51) | ALDH1A1ESR1PARP1KMT2AADAMTS5 | |
| SCHEMBL11349798 | 0.84 | TPSAB1 (0.47) | ESR1PARP1RBP4ADAMTS5TPSAB1 | |
| SCHEMBL11349055 | 0.83 | ALDH1A1 (0.48) | ALDH1A1ESR1PARP1KMT2AADAMTS5 | |
| SCHEMBL11348471 | 0.83 | RBP4 (0.41) | ALDH1A1ESR1PARP1RBP4ADAMTS5 | |
| SCHEMBL11240142 | 0.82 | SIGMAR1 (0.51) | KMT2AMEN1 | |
| SCHEMBL11233209 | 0.82 | ALDH1A1 (0.71) | ALDH1A1ESR1PARP1KMT2AMEN1 | |
| SCHEMBL11331493 | 0.80 | ALDH1A1 (0.53) | ALDH1A1ESR1PARP1KMT2ATPSAB1 | |
| SCHEMBL11224818 | 0.80 | ALDH1A1 (0.59) | ALDH1A1KMT2AMEN1TPSAB1KDM4E | |
| SCHEMBL11348285 | 0.79 | ALDH1A1 (0.45) | ALDH1A1ESR1PARP1ADAMTS5TPSAB1 | |
| SCHEMBL11354008 | 0.78 | ALDH1A1 (0.47) | ALDH1A1ESR1PARP1ADAMTS5NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4251538-A | Indolealkylamines and processes for their preparation | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-02-17 | — | — | US | disclosed |
| EP-0007399-A1 | Indolylalkyl amines, pharmaceutical preparations containing them and process for their manufacture | MERCK PATENT GmbH (DE) | 1980-02-06 | — | — | EP | disclosed |