Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TIMP3 | P35625 | 2/20 | 0.55 |
| ▸ | ENPP2 | Q13822 | 8/20 | 0.54 |
| ▸ | CASP6 | P55212 | 1/20 | 0.52 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.52 |
| ▸ | FGF1 | P05230 | 1/20 | 0.52 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.51 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.51 |
| ▸ | EP300 | Q09472 | 1/20 | 0.51 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.51 |
| ▸ | CD40 | P25942 | 1/20 | 0.47 |
| ▸ | CD40LG | P29965 | 1/20 | 0.47 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.46 |
| ▸ | F11 | P03951 | 1/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10908058 | 0.92 | ENPP2 (0.54) | TIMP3ENPP2CASP6CTDSP1FGF1 | |
| SCHEMBL11340825 | 0.89 | TIMP3 (0.55) | TIMP3ENPP2FGF1PRMT1PRMT3 | |
| SCHEMBL11433010 | 0.89 | CASP6 (0.67) | TIMP3ENPP2CASP6CTDSP1PRMT1 | |
| SCHEMBL11342360 | 0.85 | HPSE (0.48) | TIMP3ENPP2CASP6CTDSP1FGF1 | |
| SCHEMBL11422942 | 0.84 | CD40 (0.57) | ENPP2CASP6CTDSP1CD40CD40LG | |
| SCHEMBL11348333 | 0.83 | TIMP3 (0.59) | TIMP3ENPP2CASP6CTDSP1FGF1 | |
| SCHEMBL11338810 | 0.83 | ENPP2 (0.48) | ENPP2PRMT1PRMT3EP300PRMT6 | |
| SCHEMBL11351056 | 0.82 | TIMP3 (0.52) | TIMP3ENPP2CASP6CTDSP1FGF1 | |
| SCHEMBL11343839 | 0.82 | ENPP2 (0.60) | TIMP3ENPP2CASP6CTDSP1FGF1 | |
| SCHEMBL11352189 | 0.81 | TIMP3 (0.57) | TIMP3ENPP2CASP6CTDSP1FGF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4297372-A | ANTIARTHRITIC AGENTS; COLLAGENASE AND PROTEOLYTIC ENZYME INHIBITORS; BONE, SKIN, AND ORAL DISORDERS | AMERICAN CYANAMID COMPANY (US) | 1981-10-27 | — | — | US | disclosed |
| EP-0013784-A1 | C-Substituted naphthalenemonosulfonic ureides, process for their preparation and pharmaceutical compositions containing them | AMERICAN CYANAMID COMPANY (US) | 1980-08-06 | — | — | EP | disclosed |
| US-4216164-A | Ureide inhibitors of connective tissue destruction | AMERICAN CYANAMID COMPANY (US) | 1980-08-05 | — | — | US | disclosed |