Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | XBP1 | P17861 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | LIPE | Q05469 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1135154 | 0.84 | TDP1 (0.32) | TDP1KDM4ECYP3A4ALOX12ALDH1A1 | |
| SCHEMBL1135172 | 0.72 | KDM4E (0.34) | TDP1KDM4ECYP3A4ALOX12ALDH1A1 | |
| SCHEMBL1135139 | 0.72 | KDM4E (0.37) | TDP1KDM4ECYP3A4ALOX12ALDH1A1 | |
| SCHEMBL1135148 | 0.71 | CYP4F2 (0.33) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1135171 | 0.71 | ALDH1A1 (0.33) | ALDH1A1BCHELIPE | |
| SCHEMBL11449450 | 0.70 | KDM4E (0.44) | TDP1KDM4ECYP3A4ALOX12ALDH1A1 | |
| SCHEMBL4947714 | 0.69 | LMNA (0.50) | TDP1KDM4ECYP3A4ALOX12MAPK1 | |
| SCHEMBL22863896 | 0.69 | ALDH1A1 (0.33) | ALDH1A1MAPK1NPSR1 | |
| SCHEMBL2477733 | 0.68 | ACACB (0.33) | — | |
| SCHEMBL27812288 | 0.68 | LMNA (0.33) | TDP1KDM4ECYP3A4ALOX12ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1958946-B1 | PYRIDAZINE COMPOUND AND USE THEREOF | SUMITOMO CHEMICAL CO (JP) | 2011-02-23 | — | — | EP | disclosed |