Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.31 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | XBP1 | P17861 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1135148 | 0.84 | CYP4F2 (0.33) | KDM4ECYP11B2ALDH1A1SMN1; SMN2 | |
| SCHEMBL1135133 | 0.84 | TDP1 (0.33) | TDP1KDM4ECYP3A4ALOX12ALDH1A1 | |
| SCHEMBL12516029 | 0.73 | PGK1 (0.40) | CYP11B2MDM2ALDH1A1TP53MAPT | |
| SCHEMBL6179156 | 0.72 | CYP4F2 (0.34) | KDM4EALDH1A1 | |
| SCHEMBL27770834 | 0.71 | SSTR4 (0.42) | TDP1KDM4ECYP3A4ALOX12ALDH1A1 | |
| SCHEMBL1135178 | 0.70 | LMNA (0.35) | KDM4ECYP3A4ALDH1A1MAPTNPSR1 | |
| SCHEMBL1135172 | 0.70 | KDM4E (0.34) | TDP1KDM4ECYP3A4ALOX12ALDH1A1 | |
| SCHEMBL2219644 | 0.68 | USP7 (0.38) | TDP1MDM2NPC1HTTL3MBTL1 | |
| SCHEMBL4949823 | 0.68 | ACACB (0.38) | MAPK1BCHELIPESMN1; SMN2 | |
| SCHEMBL1135128 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1958946-B1 | PYRIDAZINE COMPOUND AND USE THEREOF | SUMITOMO CHEMICAL CO (JP) | 2011-02-23 | — | — | EP | disclosed |