Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | EPAS1 | Q99814 | 5/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 2/20 | 0.34 |
| ▸ | LSS | P48449 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28072437 | 0.83 | KDM4E (0.46) | KDM4EMAPTALDH1A1HSD17B10EPAS1 | |
| SCHEMBL28072438 | 0.81 | KDM4E (0.46) | KDM4EMAPTALDH1A1HSD17B10EPAS1 | |
| SCHEMBL6964514 | 0.80 | KDM4E (0.52) | KDM4EMAPTALDH1A1HSD17B10EPAS1 | |
| SCHEMBL11355875 | 0.80 | L3MBTL1 (0.33) | MAPTALDH1A1LSSL3MBTL1LMNA | |
| SCHEMBL11359600 | 0.77 | ALDH1A1 (0.46) | KDM4EMAPTALDH1A1HSD17B10EPAS1 | |
| SCHEMBL29940995 | 0.77 | EPAS1 (0.54) | KDM4EMAPTALDH1A1HSD17B10EPAS1 | |
| SCHEMBL30987223 | 0.75 | MAPT (0.60) | KDM4EMAPTALDH1A1HSD17B10EPAS1 | |
| SCHEMBL28563540 | 0.75 | MAPT (0.60) | KDM4EMAPTALDH1A1HSD17B10EPAS1 | |
| SCHEMBL24566449 | 0.75 | MAPT (0.47) | KDM4EMAPTALDH1A1HSD17B10EPAS1 | |
| SCHEMBL28167685 | 0.73 | EPAS1 (0.57) | KDM4EMAPTALDH1A1HSD17B10EPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4277477-A | TREATING CARDIAC ARRHYTHMIA | BASF AKTIENGESELLSCHAFT (DE) | 1981-07-07 | — | — | US | disclosed |
| EP-0000727-B1 | 3-(4-(1,3-DIAZACYCLOALKENE-2-YL)-PHENYL)-1,2-BENZISOTHIAZOLES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM. | BASF Aktiengesellschaft (DE) | 1980-08-20 | — | — | EP | disclosed |
| US-4206217-A | ANTIARRHYTHMIA | BASF AKTIENGESELLSCHAFT (DE) | 1980-06-03 | — | — | US | disclosed |
| EP-0000750-A1 | 1,2-Benzisothiazoles and process for their preparation | BASF Aktiengesellschaft (DE) | 1979-02-21 | — | — | EP | disclosed |
| EP-0000727-A1 | 3-(4-(1,3-Diazacycloalkene-2-yl)-phenyl)-1,2-benzisothiazoles, process for their preparation and medicaments containing them. | BASF Aktiengesellschaft (DE) | 1979-02-21 | — | — | EP | disclosed |