Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11349055 | 0.87 | ALDH1A1 (0.48) | ALDH1A1ESR1PARP1NAMPTGLA | |
| SCHEMBL11344269 | 0.87 | ALDH1A1 (0.44) | ALDH1A1ESR1PARP1NAMPTMAPT | |
| SCHEMBL11346625 | 0.87 | ALDH1A1 (0.45) | ALDH1A1TPSAB1ESR1PARP1NAMPT | |
| SCHEMBL11348285 | 0.87 | ALDH1A1 (0.45) | ALDH1A1TPSAB1ESR1PARP1NAMPT | |
| SCHEMBL11334889 | 0.85 | ALDH1A1 (0.48) | ALDH1A1TPSAB1ESR1PARP1NAMPT | |
| SCHEMBL11233209 | 0.84 | ALDH1A1 (0.71) | ALDH1A1ESR1PARP1GLAMAPT | |
| SCHEMBL11244938 | 0.83 | TPSAB1 (0.55) | ALDH1A1TPSAB1ESR1PARP1NPSR1 | |
| SCHEMBL11343261 | 0.83 | ALDH1A1 (0.45) | ALDH1A1ESR1PARP1NAMPTSMN1; SMN2 | |
| SCHEMBL11252927 | 0.81 | SIGMAR1 (0.54) | HTR2AMAPTSMN1; SMN2NPSR1KMT2A | |
| SCHEMBL11347533 | 0.81 | ALDH1A1 (0.55) | ALDH1A1TPSAB1ESR1GLAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4251538-A | Indolealkylamines and processes for their preparation | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-02-17 | — | — | US | disclosed |
| EP-0007399-A1 | Indolylalkyl amines, pharmaceutical preparations containing them and process for their manufacture | MERCK PATENT GmbH (DE) | 1980-02-06 | — | — | EP | disclosed |