SCHEMBL11356992

SCHEMBL11356992

Nc1ccc(C(=O)c2ccc(CNC(=O)CN(Cc3ccccc3)C(=O)O)cc2)c(F)c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 14/20 0.52
HDAC6 Q9UBN7 14/20 0.52
HDAC3 O15379 4/20 0.52
HDAC4 P56524 4/20 0.52
HDAC7 Q8WUI4 4/20 0.52
HDAC2 Q92769 4/20 0.52
HDAC10 Q969S8 4/20 0.52
HDAC11 Q96DB2 4/20 0.52
HDAC8 Q9BY41 4/20 0.52
HDAC9 Q9UKV0 4/20 0.52
HDAC5 Q9UQL6 4/20 0.52
NCOR2 Q9Y618 1/20 0.46
ALDH1A1 P00352 2/20 0.43
USP2 O75604 1/20 0.43
TSHR P16473 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
HTT P42858 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
NPC1 O15118 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11327507 0.80 ALDH1A1 (0.43) HDAC1HDAC6HDAC3HDAC4HDAC7
SCHEMBL7474859 0.75 HDAC1 (0.61) HDAC1HDAC6HDAC3HDAC4HDAC7
SCHEMBL29963657 0.73 PBRM1 (0.55) ALDH1A1USP2TSHRL3MBTL1HTT
SCHEMBL8865938 0.73 PBRM1 (0.55) ALDH1A1USP2TSHRL3MBTL1HTT
SCHEMBL16862476 0.68 CTSL (0.51) HDAC1HDAC6ALDH1A1TSHRL3MBTL1
SCHEMBL3531926 0.68 CES2 (0.46) HDAC1ALDH1A1TSHRHTTSMN1; SMN2
SCHEMBL14025827 0.67 KDM4E (0.59) HDAC1HDAC6HDAC3HDAC4HDAC7
SCHEMBL11325465 0.67 CTSB (0.45) HDAC6ALDH1A1TSHRHTTSMN1; SMN2
SCHEMBL11327510 0.66 HTT (0.41) ALDH1A1TSHRHTTNPSR1RAB9A
Trifluoroacetic Acid SCHEMBL29834831 0.65 CTSS (0.45) HDAC1HDAC6HDAC3HDAC4HDAC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4299767-A ANTIALDOSTERONES, HYPOTENSIVE AGENTS, TREATMENT OF HEART AND LEVER DISORDERS HOFFMANN-LA ROCHE INC. (US) 1981-11-10 US disclosed