Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 9/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11317577 | 0.78 | ADRB1 (0.47) | PDE3BPDE3ALMNAKMT2AMEN1 | |
| SCHEMBL11317207 | 0.73 | PDE3B (0.52) | PDE3BPDE3ANPSR1NPC1LMNA | |
| SCHEMBL11320635 | 0.71 | PDE3B (0.64) | PDE3BPDE3AKMT2AMEN1ALDH1A1 | |
| SCHEMBL11312325 | 0.70 | PDE3B (0.60) | PDE3BPDE3AKMT2AMEN1ALDH1A1 | |
| SCHEMBL11323296 | 0.69 | RAB9A (0.49) | PDE3BPDE3ALMNAKMT2AMEN1 | |
| SCHEMBL11313435 | 0.69 | ATM (0.41) | PDE3BPDE3ALMNAKMT2AMEN1 | |
| SCHEMBL11317240 | 0.69 | PDE3B (0.56) | PDE3BPDE3ANPSR1LMNAKMT2A | |
| SCHEMBL11070251 | 0.69 | ADRB1 (0.44) | SMN1; SMN2 | |
| SCHEMBL11062648 | 0.68 | PDE3B (0.57) | PDE3BPDE3ANPSR1LMNAKMT2A | |
| SCHEMBL11064885 | 0.67 | ADRB1 (0.44) | KMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4298739-A | ANTICOAGULANTS, ANTIINFLAMMATORY, ANTIULCER, VASODILATOR, PHOSPHODIESTERASE INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1981-11-03 | — | — | US | disclosed |