SCHEMBL1136137

SCHEMBL1136137

Cn1cc(C(=O)Nc2ccc(F)cc2-c2ccc(F)cc2)c(C(F)(F)F)n1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.54
POLB P06746 1/20 0.54
NTRK1 P04629 2/20 0.48
WDR5 P61964 2/20 0.47
CHRM3 P20309 5/20 0.45
NTRK2 Q16620 1/20 0.44
STING1 Q86WV6 1/20 0.44
GAA P10253 2/20 0.44
KDM4E B2RXH2 1/20 0.44
NPSR1 Q6W5P4 4/20 0.43
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2D6 P10635 1/20 0.43
CYP2C9 P11712 1/20 0.43
HPGD P15428 1/20 0.43
CYP2C19 P33261 1/20 0.43
NR3C1 P04150 1/20 0.43
PGR P06401 1/20 0.43
MAPK1 P28482 1/20 0.42
MAPT P10636 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16618150 0.95 LMNA (0.63) LMNAPOLBNTRK1WDR5CHRM3
SCHEMBL1136025 0.95 LMNA (0.51) LMNAPOLBNTRK1WDR5CHRM3
SCHEMBL1136177 0.94 LMNA (0.64) LMNAPOLBNTRK1WDR5CHRM3
SCHEMBL13491717 0.94 LMNA (0.52) LMNAPOLBNTRK1WDR5CHRM3
SCHEMBL5340259 0.93 LMNA (0.49) LMNAPOLBNTRK1WDR5CHRM3
SCHEMBL1144935 0.92 LMNA (0.53) LMNAPOLBNTRK1WDR5CHRM3
SCHEMBL1135680 0.91 LMNA (0.54) LMNAPOLBNTRK1WDR5NTRK2
SCHEMBL303303 0.90 LMNA (0.53) LMNAPOLBNTRK1WDR5CHRM3
SCHEMBL29445385 0.90 LMNA (0.53) LMNAPOLBNTRK1WDR5CHRM3
SCHEMBL29445400 0.90 LMNA (0.48) LMNAPOLBNTRK1WDR5CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 159 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3954214-A1 MULTIPURPOSE BIOLOGICAL COMPOSITIONS Agrivalle Brasil Industria e Comércio de Produtos Agrícolas Ltda (BR) 2022-02-16 EP claimed
US-20170215418-A1 Controlling Red Rice with Mesotrione FMC CORP (US) 2017-08-03 US claimed
US-20170196226-A1 BACILLUS AMYLOLIQUEFACIENS RTI472 COMPOSITIONS AND METHODS OF USE FOR BENEFITING PLANT GROWTH AND TREATING PLANT DISEASE FMC CORPORATION 2017-07-13 US claimed
US-9635854-B2 Controlling red rice with mesotrione FMC CORPORATION (US) 2017-05-02 US claimed
US-9622484-B2 Microbial compositions and methods of use for benefiting plant growth and treating plant disease FMC CORPORATION (US) 2017-04-18 US claimed
US-20160186273-A1 BACILLUS AMYLOLIQUEFACIENS RTI301 COMPOSITIONS AND METHODS OF USE FOR BENEFITING PLANT GROWTH AND TREATING PLANT DISEASE FMC CORPORATION 2016-06-30 US claimed
US-20160183538-A1 MICROBIAL COMPOSITIONS AND METHODS OF USE FOR BENEFITING PLANT GROWTH AND TREATING PLANT DISEASE FMC CORPORATION 2016-06-30 US claimed
US-20160183537-A1 BACILLUS AMYLOLIQUEFACIENS RTI472 COMPOSITIONS AND METHODS OF USE FOR BENEFITING PLANT GROWTH AND TREATING PLANT DISEASE FMC CORPORATION 2016-06-30 US claimed
US-20150313235-A1 Method for Controlling Weeds Using Formulations Containing Fluthiacet-Methyl and HPPD Herbicides FMC CORP (US) 2015-11-05 US claimed
EP-2285779-B1 Method for manufacturing aryl carboxamides BASF SE (DE) 2013-03-27 EP claimed
US-20110054183-A1 Method For Manufacturing Aryl Carboxamides BASF SE 2011-03-03 US claimed
US-20100197741-A1 Ternary Fungicidal Compositions Comprising Boscalid and Chlorothalonil BASF SE (DE) 2010-08-05 US claimed
EP-2205082-A1 TERNARY FUNGICIDAL COMPOSITIONS COMPRISING BOSCALID AND CHLOROTHALONIL BASF SE (DE) 2010-07-14 EP claimed
US-20100048403-A1 Method of inducing virus tolerance of plants BASF SE (DE) 2010-02-25 US claimed
US-20100035753-A1 Fungicidal Mixtures Comprising Substituted 1-methylpyrazol-4-ylcarboxanilides BASF SE (DE) 2010-02-11 US claimed
EP-2109362-A2 METHOD OF INDUCING VIRUS TOLERANCE OF PLANTS BASF SE (DE) 2009-10-21 EP claimed
EP-2061320-A2 FUNGICIDAL MIXTURES COMPRISING SUBSTITUTED 1-METHYLPYRAZOL-4-YLCARBOXANILIDES BASF SE (DE) 2009-05-27 EP claimed
WO-2009040397-A1 TERNARY FUNGICIDAL COMPOSITIONS COMPRISING BOSCALID AND CHLOROTHALONIL BASF SE (DE) 2009-04-02 WO claimed
WO-2008098928-A2 METHOD OF INDUCING VIRUS TOLERANCE OF PLANTS BASF SE (DE) 2008-08-21 WO claimed
WO-2008095890-A2 FUNGICIDAL MIXTURES COMPRISING SUBSTITUTED 1-METHYLPYRAZOL-4-YLCARBOXANILIDES BASF SE (DE) 2008-08-14 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160186273-A1 BACILLUS AMYLOLIQUEFACIENS RTI301 COMPOSITIONS AND METHODS OF USE FOR BENEFITING PLANT GROWTH AND TREATING PLANT DISEASE BTF3, MYB, AGXT LMNA 3555/4885POLB 2917/4885NTRK1 862/4885
US-20110054183-A1 Method For Manufacturing Aryl Carboxamides H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CBR3, CBR1 LMNA 2595/4885POLB 1691/4885NTRK1 1464/4885
US-20170196226-A1 BACILLUS AMYLOLIQUEFACIENS RTI472 COMPOSITIONS AND METHODS OF USE FOR BENEFITING PLANT GROWTH AND TREATING PLANT DISEASE MYB, BTF3, NRDC LMNA 3370/4885POLB 2674/4885NTRK1 633/4885
US-20100197741-A1 Ternary Fungicidal Compositions Comprising Boscalid and Chlorothalonil CBR3, CBX3, BRD3 LMNA 2608/4885POLB 3799/4885NTRK1 3774/4885
US-20100048403-A1 Method of inducing virus tolerance of plants CBR3, CBR1, CYC1 LMNA 4263/4885POLB 2802/4885NTRK1 2884/4885
US-20100035753-A1 Fungicidal Mixtures Comprising Substituted 1-methylpyrazol-4-ylcarboxanilides CBR3, CBR1, HCN2 LMNA 2198/4885POLB 4424/4885NTRK1 2150/4885
US-20160183537-A1 BACILLUS AMYLOLIQUEFACIENS RTI472 COMPOSITIONS AND METHODS OF USE FOR BENEFITING PLANT GROWTH AND TREATING PLANT DISEASE MYB, BTF3, NRDC LMNA 3370/4885POLB 2674/4885NTRK1 633/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.