Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 8/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 7/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | QPCT | Q16769 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1137048 | 0.79 | MET (0.40) | METRAB9AAXL | |
| SCHEMBL1259043 | 0.75 | CDK8 (0.41) | MAPK14METPDK1 | |
| SCHEMBL1136834 | 0.75 | MET (0.64) | METAXL | |
| SCHEMBL3912894 | 0.71 | MET (0.60) | METAXL | |
| SCHEMBL1137399 | 0.70 | MET (0.50) | MAPK14METAXL | |
| SCHEMBL1726557 | 0.70 | MAPK14 (0.44) | MAPK14METTSHR | |
| SCHEMBL1396733 | 0.69 | MET (0.51) | METAXL | |
| SCHEMBL15015162 | 0.69 | P2RX3 (0.44) | METAXL | |
| SCHEMBL1260140 | 0.67 | MET (0.38) | MAPK14METPDK1RAB9A | |
| SCHEMBL1258227 | 0.67 | ALDH1A1 (0.40) | PDK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737451-A2 | MONOCYCLIC HETEROCYCLES AS KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005117867-A2 | MONOCYCLIC HETEROCYCLES AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-12-15 | — | — | WO | disclosed |