Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 13/20 | 0.68 |
| ▸ | BACE1 | P56817 | 13/20 | 0.68 |
| ▸ | BCHE | P06276 | 10/20 | 0.68 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.55 |
| ▸ | HTR5A | P47898 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.51 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7695910 | 0.85 | ACHE (0.72) | ACHEBACE1BCHEMEN1KMT2A | |
| SCHEMBL11370258 | 0.85 | ACHE (0.61) | ACHEBACE1BCHEMEN1KMT2A | |
| SCHEMBL11367933 | 0.82 | SIGMAR1 (0.46) | ACHEBACE1BCHEMEN1KMT2A | |
| SCHEMBL14367985 | 0.82 | ACHE (1.00) | ACHEBACE1BCHEMEN1KMT2A | |
| SCHEMBL1803081 | 0.79 | ACHE (1.00) | ACHEBACE1BCHEMEN1KMT2A | |
| SCHEMBL11374561 | 0.78 | ACHE (0.67) | ACHEBACE1BCHEMEN1KMT2A | |
| SCHEMBL11386928 | 0.77 | CXCR4 (0.57) | MEN1KMT2ACXCR4POLBSIGMAR1 | |
| SCHEMBL4036986 | 0.77 | ACHE (0.76) | ACHEBACE1BCHEMEN1KMT2A | |
| SCHEMBL11371722 | 0.77 | ACHE (0.50) | ACHEBACE1BCHEMEN1KMT2A | |
| SCHEMBL11378628 | 0.76 | ACHE (0.52) | ACHEBACE1BCHEMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4267318-A | 1-(Diarylmethyl)-4-piperidinamine and derivatives thereof | G. D. SEARLE & CO. (US) | 1981-05-12 | — | — | US | disclosed |