Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.33 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11387048 | 0.88 | ALDH1A1 (0.40) | ALDH1A1CCR5MEN1KMT2AMAPK14 | |
| SCHEMBL11385796 | 0.79 | ALDH1A1 (0.41) | CYP19A1CYP11B1CYP11B2PDE4BALDH1A1 | |
| SCHEMBL8601015 | 0.77 | MEN1 (0.44) | ALDH1A1MAPTKDM4CHTR2CHTR2B | |
| SCHEMBL11394040 | 0.76 | CYP19A1 (0.45) | CYP19A1CYP11B1CYP11B2ALDH1A1MAPT | |
| SCHEMBL8601204 | 0.73 | CCR5 (0.45) | ALDH1A1MAPTHTR2CHTR2BCCR5 | |
| SCHEMBL27252708 | 0.71 | MAPT (0.44) | ALDH1A1MAPTCCR5MEN1KMT2A | |
| SCHEMBL8601010 | 0.69 | LMNA (0.46) | MAPTMEN1KMT2ACYP2D6HRH3 | |
| SCHEMBL17542808 | 0.69 | CHRM5 (0.39) | PDE4BALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL10691066 | 0.68 | DHFR (0.39) | ALDH1A1MAPTHTR2CHTR2BCCR5 | |
| SCHEMBL17543630 | 0.68 | HCRTR1 (0.38) | PDE4BALDH1A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4302588-A | 5-(3-SUBSTITUTED AMINO)-2-HYDROXY-PROPYLOXY)-8-HYDROXY OR ALKOXY-CARBOSTYRILS, ADRENERGIC BLOCKING AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1981-11-24 | — | — | US | disclosed |