Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 5/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11383677 | 1.00 | PTGS2 (0.35) | PTGS2MAOBCYP19A1ALDH1A1RAB9A | |
| SCHEMBL11381322 | 0.77 | ALDH1A1 (0.61) | ALDH1A1RAB9ALMNASMN1; SMN2MAPT | |
| SCHEMBL11382147 | 0.71 | CYP19A1 (0.35) | CYP19A1ALDH1A1RAB9ALMNASMN1; SMN2 | |
| SCHEMBL10482627 | 0.67 | RIPK1 (0.37) | ALDH1A1RAB9ALMNASMN1; SMN2MAPT | |
| SCHEMBL11372709 | 0.67 | CNR2 (0.42) | GAACNR1CNR2 | |
| SCHEMBL12479183 | 0.65 | MAOB (0.40) | PTGS2MAOBALDH1A1HPGDMAOA | |
| SCHEMBL11808579 | 0.62 | GRIN2D (0.47) | PTGS2MAOBALDH1A1TSHRHPGD | |
| SCHEMBL11372935 | 0.62 | RIPK1 (0.32) | ALDH1A1 | |
| SCHEMBL8356678 | 0.62 | CYP19A1 (0.50) | MAOBCYP19A1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL2761874 | 0.60 | PDK2 (0.43) | PTGS2MAOBALDH1A1NPSR1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4243674-A | HYPOTENSIVE AGENTS; ANALGESICS; ANTISECRETORY AGENTS; ANTIBODY INHIBITORS, AND TRANQUILIZERS | PFIZER INC. (US) | 1981-01-06 | — | — | US | disclosed |
| US-4143139-A | ANALGESICS, HYPOTENSIVES, IMMUNOSUPPRESSANTS, TRANQUILIZERS, ANTISECRETORY, ANTI-ANXIETY | PFIZER INC. (US) | 1979-03-06 | — | — | US | disclosed |