SCHEMBL11386609

SCHEMBL11386609

CN1CCCC1Cc1cc(Cl)c(Cl)cc1Cl

nearest known ligand 0.51

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
HTR1B P28222 6/20 0.50
HTR1D P28221 4/20 0.50
HTR6 P50406 5/20 0.47
HTR1A P08908 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11370835 0.83 TSHR (0.51) HTR1BHTR1DHTR6
SCHEMBL11375404 0.79 HTR6 (0.56) HTR1BHTR1DHTR6HTR1A
SCHEMBL11469642 0.73 HTR6 (0.50) HTR1BHTR1DHTR6HTR1A
SCHEMBL11369857 0.71 CHRNB2 (0.54) HTR1BHTR1DHTR6HTR1A
SCHEMBL13162969 0.70 HTR6 (0.57) HTR1BHTR1DHTR6
SCHEMBL11379296 0.70 HTR6 (0.47) HTR1BHTR1DHTR6HTR1A
SCHEMBL11372986 0.70 ADRA1A (0.55) HTR1BHTR1DHTR6HTR1A
SCHEMBL13162973 0.69 HTR2A (0.61) HTR1BHTR1DHTR6
Ammonia Solution, Strong SCHEMBL29771408 0.68 HTR1D (0.49) HTR1BHTR1DHTR6
SCHEMBL9242412 0.68 CHRNB4 (0.65)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4279918-A ANTIDEPRESSANTS, STIMULANTS BYK GULDEN LOMBERG CHEMISCHE FABRIK G.M.B.H. (DE) 1981-07-21 US disclosed