SCHEMBL1140705

SCHEMBL1140705

C=CCC1=CC(=O)c2ccccc2C1=O

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.47
KMT2A Q03164 3/20 0.47
L3MBTL1 Q9Y468 2/20 0.47
NSD2 O96028 1/20 0.47
PTPN1 P18031 1/20 0.47
PTPRC P08575 1/20 0.46
PKM P14618 3/20 0.46
ALDH1A1 P00352 3/20 0.46
LMNA P02545 3/20 0.46
MAPT P10636 3/20 0.46
MAPK1 P28482 3/20 0.46
IDO1 P14902 2/20 0.46
CDC25A P30304 2/20 0.46
CDC25B P30305 2/20 0.46
GAA P10253 2/20 0.46
HPGD P15428 2/20 0.46
ATM Q13315 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
PLIN1 O60240 1/20 0.46
NR1I2 O75469 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phosphine SCHEMBL14764881 0.98 MEN1 (0.46) MEN1KMT2AL3MBTL1NSD2PTPN1
SCHEMBL7777410 0.79 MEN1 (0.45) MEN1KMT2AL3MBTL1NSD2PTPN1
SCHEMBL9685830 0.79 PTPN1 (0.52) MEN1KMT2AL3MBTL1NSD2PTPN1
SCHEMBL5810776 0.78 PARK7 (0.58) MEN1KMT2AL3MBTL1NSD2PTPN1
SCHEMBL20375471 0.77 MEN1 (0.48) MEN1KMT2AL3MBTL1NSD2PTPN1
Deoxylapachol SCHEMBL2682330 0.77 MEN1 (0.54) MEN1KMT2AL3MBTL1NSD2PTPN1
SCHEMBL11218822 0.77 MAPT (0.54) MEN1KMT2AALDH1A1LMNAMAPT
SCHEMBL4784119 0.75 PTPN1 (0.38) MEN1KMT2AL3MBTL1NSD2PTPN1
SCHEMBL7912021 0.75 PTPN1 (0.52) MEN1KMT2AL3MBTL1NSD2PTPN1
SCHEMBL3275939 0.75 PTPN1 (0.52) MEN1KMT2AL3MBTL1NSD2PTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0065513-B1 ANTIMYCOTIC SYNERGISTIC PHARMACEUTICAL COMPOSITIONS AND PROCESS FOR THE PREPARATION THEREOF CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) 1985-09-18 EP claimed
EP-0065513-A4 ANTIMYCOTIC SYNERGISTIC PHARMACEUTICAL COMPOSITIONS AND PROCESS FOR THE PREPARATION THEREOF. CHINOIN GYOGYSZER ES VEGYESZET (HU) 1983-03-29 EP claimed
EP-0065513-A1 ANTIMYCOTIC SYNERGISTIC PHARMACEUTICAL COMPOSITIONS AND PROCESS FOR THE PREPARATION THEREOF. CHINOIN GYOGYSZER ES VEGYESZET (HU) 1982-12-01 EP claimed
WO-1982001821-A1 ANTIMYCOTIC SYNERGISTIC PHARMACEUTICAL COMPOSITIONS AND PROCESS FOR THE PREPARATION THEREOF KOVACS ANDRAS 1982-06-10 WO claimed
CN-109310604-A Use of specific compounds for modifying, reducing or eliminating off-flavours 西姆莱斯有限公司 2019-02-05 CN disclosed
US-20180049997-A1 CHOLESTERYL ESTER TRANSFER PROTEIN (CETP) INHIBITION IN THE TREATMENT OF CANCER KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY (SA) 2018-02-22 US disclosed
US-9890106-B2 Anti-cancer lead molecule KING ABDULLAH UNIVERSITY OF SCIENCE & TECHNOLOGY (SA) 2018-02-13 US disclosed
EP-3261628-A1 CHOLESTERYL ESTER TRANSFER PROTEIN (CETP) INHIBITION IN THE TREATMENT OF CANCER King Abdullah University Of Science And Technology (SA) 2018-01-03 EP disclosed
WO-2016135633-A1 CHOLESTERYL ESTER TRANSFER PROTEIN (CETP) INHIBITION IN THE TREATMENT OF CANCER KING ABDULLAH UNIVERSITY OF SCIENCE & TECHNOLOGY (SA) 2016-09-01 WO disclosed
EP-2844237-A1 ANTI-CANCER LEAD MOLECULE King Abdullah University Of Science And Technology (SA) 2015-03-11 EP disclosed
US-20140107196-A1 ANTI-CANCER LEAD MOLECULE KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY (SA) 2014-04-17 US disclosed
WO-2013164683-A1 ANTI-CANCER LEAD MOLECULE KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY (SA) 2013-11-07 WO disclosed
EP-0065513-B1 ANTIMYCOTIC SYNERGISTIC PHARMACEUTICAL COMPOSITIONS AND PROCESS FOR THE PREPARATION THEREOF CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) 1985-09-18 EP disclosed
US-4507241-A Method for the hydrocarbylation of naphthoquinone derivatives E. I. DU PONT DE NEMOURS AND COMPANY (US) 1985-03-26 US disclosed
EP-0065513-A4 ANTIMYCOTIC SYNERGISTIC PHARMACEUTICAL COMPOSITIONS AND PROCESS FOR THE PREPARATION THEREOF. CHINOIN GYOGYSZER ES VEGYESZET (HU) 1983-03-29 EP disclosed
EP-0065513-A1 ANTIMYCOTIC SYNERGISTIC PHARMACEUTICAL COMPOSITIONS AND PROCESS FOR THE PREPARATION THEREOF. CHINOIN GYOGYSZER ES VEGYESZET (HU) 1982-12-01 EP disclosed
WO-1982001821-A1 ANTIMYCOTIC SYNERGISTIC PHARMACEUTICAL COMPOSITIONS AND PROCESS FOR THE PREPARATION THEREOF KOVACS ANDRAS 1982-06-10 WO disclosed
US-4110473-A MITICIDAL ETHERS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1978-08-29 US disclosed
US-T962009-I4 Reduction of 2-acyl-1-naphthols to 2-alkyl-1-naphthols Fugitt, Robert Benson (US) 1977-09-06 US disclosed
US-3953482-A HYDROGEN CHLORIDE CATALYST MITSUBISHI GAS CHEMICAL COMPANY, INC. (JA) 1976-04-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140107196-A1 ANTI-CANCER LEAD MOLECULE ACAT2, BRCA1, ALPG MEN1 4585/4885KMT2A 1124/4885L3MBTL1 29/4885
US-20180049997-A1 CHOLESTERYL ESTER TRANSFER PROTEIN (CETP) INHIBITION IN THE TREATMENT OF CANCER CETP, LCAT, MTTP MEN1 3274/4885KMT2A 890/4885L3MBTL1 547/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.