Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 11/20 | 0.57 |
| ▸ | RAB9A | P51151 | 11/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | TP53 | P04637 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 3/20 | 0.55 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.55 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11208093 | 0.94 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL11207092 | 0.90 | GAA (0.59) | NPC1RAB9ASMN1; SMN2PKMMAPT | |
| SCHEMBL11213148 | 0.78 | RAB9A (0.52) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL10947493 | 0.76 | TAAR1 (0.49) | NPC1RAB9ASMN1; SMN2PKMALDH1A1 | |
| SCHEMBL7470030 | 0.74 | RAB9A (1.00) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL5443581 | 0.73 | NPC1 (0.77) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL11206271 | 0.73 | ALPL (0.46) | NPC1RAB9ASMN1; SMN2TP53PKM | |
| SCHEMBL15330952 | 0.73 | NPC1 (0.72) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL2683107 | 0.72 | NPC1 (0.76) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL3409592 | 0.72 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2TP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0035863-A1 | Imidazole derivatives, process for their preparation and pharmaceutical compositions thereof | Pfizer Limited (GB) | 1981-09-16 | — | — | EP | claimed |