Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | AGXT | P21549 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL666545 | 0.85 | TSHR (0.57) | TSHRIDO1AGXTALDH1A1MAOB | |
| SCHEMBL1535619 | 0.80 | TSHR (0.46) | TSHRIDO1AGXTALDH1A1MAOB | |
| SCHEMBL16594360 | 0.80 | TSHR (0.46) | TSHRIDO1AGXTALDH1A1MAOB | |
| SCHEMBL16594361 | 0.80 | TSHR (0.46) | TSHRIDO1AGXTALDH1A1MAOB | |
| SCHEMBL7054396 | 0.77 | TSHR (0.43) | TSHRIDO1AGXTALDH1A1MAPT | |
| SCHEMBL58206 | 0.76 | TSHR (0.52) | TSHRIDO1AGXTALDH1A1MAOB | |
| SCHEMBL7054637 | 0.76 | TSHR (0.46) | TSHRIDO1AGXTALDH1A1MAOB | |
| SCHEMBL15536184 | 0.74 | TSHR (0.44) | TSHRIDO1AGXTALDH1A1MAOB | |
| SCHEMBL6873209 | 0.73 | TSHR (0.55) | TSHRIDO1AGXTALDH1A1MAOB | |
| SCHEMBL201538 | 0.73 | TSHR (0.48) | TSHRIDO1AGXTALDH1A1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1120 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110267958-A | Process for preparing pyrazolo [1,5-a ] pyrimidines and salts thereof | 阿雷生物药品公司 | 2019-09-20 | — | — | CN | claimed |
| EP-3532475-A2 | PROCESS FOR THE PREPARATION OF PYRAZOLO[1,5-a]PYRIMIDINES AND SALTS THEREOF | Array Biopharma Inc. (US) | 2019-09-04 | — | — | EP | claimed |
| CN-109705063-A | The synthetic method of entecavir midbodies and its synthetic method and Entecavir | 广州市朗启医药科技有限责任公司 | 2019-05-03 | — | — | CN | claimed |
| WO-2019005796-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLO[1,5-a]PYRIMIDINES AND SALTS THEREOF | ZHAO QIAN (US) | 2019-01-03 | — | — | WO | claimed |
| CN-108276408-A | A kind of intermediate of tributidine and its preparation method and application | 上海皓元医药股份有限公司 | 2018-07-13 | — | — | CN | claimed |
| WO-2018081417-A2 | PROCESS FOR THE PREPARATION OF PYRAZOLO[1,5-a]PYRIMIDINES AND SALTS THEREOF | ZHAO QIAN (US) | 2018-05-03 | — | — | WO | claimed |
| EP-3291792-A2 | PROCESS FOR TREATING KERATIN MATERIALS USING AMIDE, ACID OR ESTER C-GLYCOSIDE DERIVATIVES, AND COSMETIC COMPOSITION CONTAINING SAME | L'Oréal (FR) | 2018-03-14 | — | — | EP | claimed |
| CN-103159808-B | A kind of process for preparing natural sweetener | 上海泓博智源医药股份有限公司 | 2017-03-29 | — | — | CN | claimed |
| WO-2016177908-A2 | PROCESS FOR TREATING KERATIN MATERIALS USING AMIDE, ACID OR ESTER C-GLYCOSIDE DERIVATIVES, AND COSMETIC COMPOSITION CONTAINING SAME | L'OREAL (FR) | 2016-11-10 | — | — | WO | claimed |
| CN-103221382-B | Preparation pet precursor | GE HEALTHCARE LTD. (GB) | 2016-06-01 | — | — | CN | claimed |
| WO-2008047174-A1 | ALPHA-GALACTOSYLCERAMIDE ANALOGS, THEIR METHODS OF MANUFACTURE, INTERMEDIATE COMPOUNDS USEFUL IN THESE METHODS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2008-04-24 | — | — | WO | claimed |
| EP-1740522-A2 | BISPHENYL COMPOUNDS USEFUL AS VITAMIN D SB 3 /SB RECEPTOR AGONISTS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2007-01-10 | — | — | EP | claimed |
| US-6982263-B2 | Nitriles useful as reversible inhibitors of cysteine proteases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2006-01-03 | — | — | US | claimed |
| WO-2005087700-A2 | BISPHENYL COMPOUNDS USEFUL AS VITAMIN D3 RECEPTOR AGONISTS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2005-09-22 | — | — | WO | claimed |
| US-20030119827-A1 | Novel nitriles useful as reversible inhibitors of cysteine proteases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2003-06-26 | — | — | US | claimed |
| EP-0711773-B1 | HYMENIALDISINE AND DERIVATIVE THEREOF, PROCESS FOR PRODUCING INTERMEDIATE FOR SYNTHESIZING THE SAME, AND SAID INTERMEDIATE | SUNTORY LTD (JP) | 2001-09-12 | — | — | EP | claimed |
| WO-1998016537-A1 | NOVEL COMPOUNDS | ASTRA AKTIEBOLAG (PUBL) (SE) | 1998-04-23 | — | — | WO | claimed |
| EP-0772600-A1 | 1,2-SUBSTITUTED IMIDAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | claimed |
| US-5620999-A | ANTIARTHRITIC, ANALGESIC AND ANTIPYRATIC AGENT | G.D. SEARLE & CO. | 1997-04-15 | — | — | US | claimed |
| WO-1996003388-A1 | 1,2-SUBSTITUTED IMIDAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030119827-A1 | Novel nitriles useful as reversible inhibitors of cysteine proteases | NOS1, CTSK, CTSS | TSHR 3975/4885IDO1 2223/4885AGXT 4003/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.