Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 6/20 | 0.61 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.41 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.39 |
| ▸ | MDM4 | O15151 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.39 |
| ▸ | CDC25B | P30305 | 4/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.39 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL750344 | 0.90 | PDE2A (0.72) | PDE2AHTR1ABCHEADORA2AADORA2B | |
| SCHEMBL6293320 | 0.84 | HTR1A (0.56) | PDE2AHTR1ABCHETP53MDM2 | |
| SCHEMBL9097705 | 0.83 | PDE2A (0.70) | PDE2AHTR1ABCHETP53 | |
| SCHEMBL8764444 | 0.83 | PDE2A (0.70) | PDE2AHTR1ABCHEADORA2AADORA2B | |
| SCHEMBL11427985 | 0.80 | PDE2A (0.64) | PDE2AHTR1ABCHEADORA2AADORA2B | |
| SCHEMBL5961364 | 0.80 | PDE2A (0.64) | PDE2AHTR1ABCHEADORA2AADORA2B | |
| SCHEMBL6306351 | 0.80 | PDE2A (0.61) | PDE2AHTR1ABCHEADORA2AADORA2B | |
| SCHEMBL6306348 | 0.80 | PDE2A (0.61) | PDE2AHTR1ABCHEADORA2AADORA2B | |
| SCHEMBL9098922 | 0.80 | PDE2A (0.65) | PDE2AHTR1ABCHE | |
| SCHEMBL750739 | 0.77 | BCHE (0.68) | PDE2AHTR1ABCHEADORA2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4188378-A | Anticancer and antiviral activity of 9-β-D-arabinofuranosyl-2-fluoroadenine | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH, EDUCATION AND WELFARE (US) | 1980-02-12 | — | — | US | disclosed |