Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 8/20 | 0.70 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | BCHE | P06276 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | NT5E | P21589 | 5/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9098922 | 0.88 | PDE2A (0.65) | PDE2AHTR1ABCHENT5EADORA3 | |
| SCHEMBL11420439 | 0.83 | PDE2A (0.61) | PDE2AHTR1ABCHETP53 | |
| SCHEMBL8764444 | 0.83 | PDE2A (0.70) | PDE2AHTR1ABCHENT5EADORA3 | |
| SCHEMBL750344 | 0.82 | PDE2A (0.72) | PDE2AHTR1ABCHELMNANT5E | |
| SCHEMBL11119972 | 0.82 | HTR1A (0.56) | PDE2AHTR1ABCHENT5E | |
| SCHEMBL14429061 | 0.81 | PDE2A (0.55) | PDE2AHTR1ABCHEADORA3 | |
| SCHEMBL14429165 | 0.80 | PDE2A (0.55) | PDE2AHTR1ABCHETP53TDP1 | |
| SCHEMBL14429059 | 0.80 | TYMP (0.57) | PDE2AHTR1ABCHETP53TDP1 | |
| SCHEMBL11427985 | 0.80 | PDE2A (0.64) | PDE2AHTR1ABCHENT5EADORA3 | |
| SCHEMBL5961364 | 0.80 | PDE2A (0.64) | PDE2AHTR1ABCHENT5EADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5539098-A | 5'-O-propionyl and 5'-O-butyryl esters of 2-amino-6-methoxy-9-(β-D-arabinofuranosyl)-9H-purine | GLAXO WELLCOME INC. (US) | 1996-07-23 | — | — | US | disclosed |
| US-5424295-A | Useful in treatment of varicella-zoster virus infections | BURROUGHS WELLCOME CO. (US) | 1995-06-13 | — | — | US | disclosed |
| EP-0294114-A2 | Antiviral compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1988-12-07 | — | — | EP | disclosed |
| US-4188378-A | Anticancer and antiviral activity of 9-β-D-arabinofuranosyl-2-fluoroadenine | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH, EDUCATION AND WELFARE (US) | 1980-02-12 | — | — | US | disclosed |
| US-4081534-A | Amino purine nucleosides as autoimmune suppressant agents | BURROUGHS WELLCOME CO. (US) | 1978-03-28 | — | — | US | disclosed |