Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 3/20 | 0.65 |
| ▸ | BCHE | P06276 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | NT5E | P21589 | 7/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.49 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9097705 | 0.88 | PDE2A (0.70) | PDE2ABCHEHTR1ANT5EADORA3 | |
| SCHEMBL11420439 | 0.80 | PDE2A (0.61) | PDE2ABCHEHTR1A | |
| SCHEMBL750739 | 0.80 | BCHE (0.68) | PDE2ABCHEHTR1ANT5EADORA3 | |
| SCHEMBL8764444 | 0.79 | PDE2A (0.70) | PDE2ABCHEHTR1ANT5EADORA3 | |
| SCHEMBL750344 | 0.78 | PDE2A (0.72) | PDE2ABCHEHTR1ANT5EADORA3 | |
| SCHEMBL14429061 | 0.76 | PDE2A (0.55) | PDE2ABCHEHTR1AADORA3 | |
| SCHEMBL11427985 | 0.76 | PDE2A (0.64) | PDE2ABCHEHTR1ANT5EADORA3 | |
| SCHEMBL5961364 | 0.76 | PDE2A (0.64) | PDE2ABCHEHTR1ANT5EADORA3 | |
| SCHEMBL11119972 | 0.76 | HTR1A (0.56) | PDE2ABCHEHTR1ANT5E | |
| SCHEMBL8817923 | 0.76 | PDE2A (0.47) | PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5539098-A | 5'-O-propionyl and 5'-O-butyryl esters of 2-amino-6-methoxy-9-(β-D-arabinofuranosyl)-9H-purine | GLAXO WELLCOME INC. (US) | 1996-07-23 | — | — | US | disclosed |
| US-5424295-A | Useful in treatment of varicella-zoster virus infections | BURROUGHS WELLCOME CO. (US) | 1995-06-13 | — | — | US | disclosed |