Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 9/20 | 0.88 |
| ▸ | PGR | P06401 | 8/20 | 0.88 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.88 |
| ▸ | LMNA | P02545 | 4/20 | 0.88 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.88 |
| ▸ | USP2 | O75604 | 3/20 | 0.88 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.88 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.88 |
| ▸ | AR | P10275 | 2/20 | 0.66 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.66 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.65 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.65 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.61 |
| ▸ | TNF | P01375 | 1/20 | 0.61 |
| ▸ | IL6 | P05231 | 1/20 | 0.61 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.61 |
| ▸ | GLUL | P15104 | 1/20 | 0.61 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11574271 | 0.95 | PGR (0.83) | NR3C1PGRHIF1ALMNACYP3A4 | |
| SCHEMBL11016446 | 0.95 | PGR (0.80) | NR3C1PGRHIF1ALMNACYP3A4 | |
| SCHEMBL11016450 | 0.95 | PGR (0.80) | NR3C1PGRHIF1ALMNACYP3A4 | |
| SCHEMBL11574275 | 0.95 | PGR (0.83) | NR3C1PGRHIF1ALMNACYP3A4 | |
| SCHEMBL5602245 | 0.95 | PGR (0.80) | NR3C1PGRHIF1ALMNACYP3A4 | |
| SCHEMBL5602237 | 0.95 | PGR (0.80) | NR3C1PGRHIF1ALMNACYP3A4 | |
| SCHEMBL730945 | 0.94 | HIF1A (0.79) | NR3C1PGRHIF1ALMNACYP3A4 | |
| Prednicarbate SCHEMBL3942 | 0.94 | NR3C1 (1.00) | NR3C1PGRHIF1ALMNACYP3A4 | |
| Prednicarbate SCHEMBL1650745 | 0.94 | NR3C1 (1.00) | NR3C1PGRHIF1ALMNACYP3A4 | |
| Prednicarbate SCHEMBL5483489 | 0.94 | NR3C1 (1.00) | NR3C1PGRHIF1ALMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4201778-A | 6-Acyloxy-1,4,6-pregnatrienes, their use as anti-inflammatory agents, methods for their manufacture, and 6-oxo-1,4-pregnadiene intermediates | SCHERING CORPORATION (US) | 1980-05-06 | — | — | US | disclosed |
| EP-0001864-A1 | Novel 6-oxygenated-3,20-dioxo-pregnane derivatives, process for the preparation thereof, and pharmaceutical compositions containing them | Technobiotic Ltd. (CH) | 1979-05-16 | — | — | EP | disclosed |