Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.49 |
| ▸ | ECE1 | P42892 | 1/20 | 0.48 |
| ▸ | TTR | P02766 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.47 |
| ▸ | BCHE | P06276 | 3/20 | 0.47 |
| ▸ | ACHE | P22303 | 3/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11485002 | 0.91 | MMP12 (0.52) | AKR1B1SMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL29539979 | 0.84 | TTR (0.58) | AKR1B1SMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL11423247 | 0.84 | CSNK2A2 (0.43) | AKR1B1SMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL11067358 | 0.84 | TTR (0.58) | AKR1B1SMN1; SMN2MEN1KMT2ANPC1 | |
| Furcloprofen SCHEMBL30608641 | 0.82 | PTGS2 (0.56) | MEN1KMT2APTGS2TTRPTGS1 | |
| SCHEMBL11422966 | 0.82 | AKR1C3 (0.43) | AKR1B1MEN1KMT2ACYP1A2CYP2C9 | |
| Furcloprofen SCHEMBL287046 | 0.82 | PTGS2 (0.56) | MEN1KMT2APTGS2TTRPTGS1 | |
| SCHEMBL11434266 | 0.81 | GABRP (0.50) | SMN1; SMN2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL29887131 | 0.80 | MEN1 (0.51) | SMN1; SMN2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL9916225 | 0.80 | AHR (0.53) | SMN1; SMN2MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4222944-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIRHEUMATIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1980-09-16 | — | — | US | disclosed |
| US-4192809-A | USED A ANTIINFLAMMATORY, ANALGESIC, AND ANTIRHEUMATIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1980-03-11 | — | — | US | disclosed |
| US-4097497-A | ANTIINFLAMMATORY, ANALGESICS, ANTIRHEUMATIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1978-06-27 | — | — | US | disclosed |
| US-4022805-A | ANTIINFLAMMATORY, ANALGESIC, ANTIRHEUMATIC | HOFFMANN-LA ROCHE INC. (US) | 1977-05-10 | — | — | US | disclosed |