Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 7/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10903897 | 0.86 | L3MBTL1 (0.55) | MAOBALOX5MEN1KMT2ALMNA | |
| SCHEMBL10481838 | 0.86 | MAPT (0.50) | MAOBALOX5MEN1KMT2ALMNA | |
| SCHEMBL407850 | 0.86 | MAOB (0.47) | MAOBALOX5MEN1KMT2ALMNA | |
| SCHEMBL28512566 | 0.85 | SMN1; SMN2 (0.49) | MAOBMEN1KMT2AL3MBTL1MAPT | |
| SCHEMBL10477402 | 0.85 | APP (0.53) | MAOBALOX5MEN1KMT2ALMNA | |
| SCHEMBL7535983 | 0.85 | LMNA (0.53) | MAOBLMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL12567822 | 0.84 | GSTP1 (0.55) | MAOBALOX5LMNACYP1A2PTGS1 | |
| SCHEMBL348875 | 0.83 | MEN1 (0.55) | MAOBMEN1KMT2ALMNAL3MBTL1 | |
| SCHEMBL14291457 | 0.83 | TSHR (0.49) | MAOBALOX5MEN1KMT2ALMNA | |
| SCHEMBL8555303 | 0.83 | KDM1A (0.49) | MAOBALOX5MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9486435-B2 | (Het)aryl-p-quinone derivatives for treatment of mitochondrial diseases | EDISON PHARMACEUTICALS, INC. (US) | 2016-11-08 | — | — | US | disclosed |
| US-20150297551-A1 | (HET)ARYL-P-QUINONE DERIVATIVES FOR TREATMENT OF MITOCHONDRIAL DISEASES | PTC THERAPEUTICS, INC. | 2015-10-22 | — | — | US | disclosed |
| US-8952071-B2 | (Het)aryl-p-quinone derivatives for treatment of mitochondrial diseases | EDISON PHARMACEUTICALS, INC. (US) | 2015-02-10 | — | — | US | disclosed |
| US-20110046219-A1 | (HET)ARYL-P-QUINONE DERIVATIVES FOR TREATMENT OF MITOCHONDRIAL DISEASES | EDISON PHARMACEUTICALS, INC | 2011-02-24 | — | — | US | disclosed |
| EP-2237664-A1 | (HET) ARYL-p-QUINONE DERIVATIVES FOR TREATMENT OF MITOCHONDRIAL DISEASES | Edison Pharmaceuticals, Inc. (US) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009089224-A1 | (HET) ARYL-p-QUINONE DERIVATIVES FOR TREATMENT OF MITOCHONDRIAL DISEASES | EDISON PHARMACEUTICALS, INC. (US) | 2009-07-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150297551-A1 | (HET)ARYL-P-QUINONE DERIVATIVES FOR TREATMENT OF MITOCHONDRIAL DISEASES | FH, ECHS1, NDUFS6 | MAOB 877/4885ALOX5 394/4885MEN1 3805/4885 |
| US-20110046219-A1 | (HET)ARYL-P-QUINONE DERIVATIVES FOR TREATMENT OF MITOCHONDRIAL DISEASES | FH, ECHS1, NDUFS6 | MAOB 877/4885ALOX5 394/4885MEN1 3805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.