Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 4/20 | 0.62 |
| ▸ | HTR1A | P08908 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.49 |
| ▸ | GMNN | O75496 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11446408 | 0.91 | HTR1A (0.50) | HTR7HTR1AMEN1KMT2AMAPT | |
| SCHEMBL11446337 | 0.90 | HTR1A (0.52) | HTR7HTR1ADRD2 | |
| SCHEMBL11447022 | 0.90 | HTR1A (0.49) | HTR7HTR1AMEN1KMT2AMAPT | |
| SCHEMBL11447343 | 0.89 | ADRB2 (0.52) | HTR7HTR1AMEN1KMT2AMAPT | |
| SCHEMBL11446599 | 0.89 | ADRA1D (0.51) | HTR7HTR1AMEN1KMT2AMAPT | |
| Hydrochloric Acid SCHEMBL11457400 | 0.88 | ADRA1D (0.53) | HTR7HTR1AMEN1KMT2AMAPT | |
| SCHEMBL11446383 | 0.88 | HTR1A (0.59) | HTR7HTR1AMEN1KMT2AMAPT | |
| SCHEMBL11454790 | 0.88 | HTR1A (0.49) | HTR7HTR1AMEN1KMT2AMAPT | |
| SCHEMBL11447167 | 0.88 | ADRA1D (0.48) | HTR7HTR1AMEN1KMT2AMAPT | |
| SCHEMBL11456957 | 0.84 | ALDH1A1 (0.47) | HTR7HTR1AKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4205173-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1980-05-27 | — | — | US | disclosed |
| US-4085107-A | ANALGESICS | PENNWALT CORPORATION (US) | 1978-04-18 | — | — | US | disclosed |
| US-4060526-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1977-11-29 | — | — | US | disclosed |