Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.52 |
| ▸ | HTR7 | P34969 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 3/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | ESRRG | P62508 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11446408 | 0.91 | HTR1A (0.50) | HTR1AHTR7ADRA1AADRA1DADRA1B | |
| SCHEMBL11446299 | 0.90 | HTR7 (0.62) | HTR1AHTR7DRD2 | |
| SCHEMBL11447022 | 0.90 | HTR1A (0.49) | HTR1AHTR7DRD2ADRA1AADRA1D | |
| SCHEMBL11446599 | 0.89 | ADRA1D (0.51) | HTR1AHTR7ADRA1AADRA1DADRA1B | |
| SCHEMBL11456957 | 0.88 | ALDH1A1 (0.47) | HTR1AHTR7ADRA1AADRA1DADRA1B | |
| Hydrochloric Acid SCHEMBL11457400 | 0.88 | ADRA1D (0.53) | HTR1AHTR7ADRA1AADRA1DADRA1B | |
| SCHEMBL11446383 | 0.88 | HTR1A (0.59) | HTR1AHTR7DRD2ADRA1AADRA1D | |
| SCHEMBL11446875 | 0.86 | ADRA1D (0.52) | HTR1AHTR7ADRA1AADRA1DADRA1B | |
| SCHEMBL11447611 | 0.86 | ADRA1D (0.52) | HTR1AHTR7ADRA1AADRA1DADRA1B | |
| SCHEMBL11446219 | 0.84 | ADRA1D (0.45) | HTR1AHTR7ADRA1AADRA1DADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4205173-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1980-05-27 | — | — | US | disclosed |
| US-4085107-A | ANALGESICS | PENNWALT CORPORATION (US) | 1978-04-18 | — | — | US | disclosed |
| US-4060526-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1977-11-29 | — | — | US | disclosed |