SCHEMBL1144947

SCHEMBL1144947

CC(=O)c1nn(C(C)C)cc1O

nearest known ligand 0.40

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 5/20 0.40
ADORA1 P30542 5/20 0.40
ACHE P22303 2/20 0.38
ADORA3 P0DMS8 3/20 0.35
AADAT Q8N5Z0 1/20 0.33
POLB P06746 1/20 0.31
HTT P42858 1/20 0.31
ALOX15 P16050 1/20 0.30
ALOX12 P18054 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1144387 0.74 LMNA (0.36) ADORA2AADORA1POLB
SCHEMBL23400639 0.71 ADORA2A (0.33) ADORA2AADORA1ACHEADORA3AADAT
SCHEMBL23398566 0.69 ADORA2A (0.33) ADORA2AADORA1ACHEAADAT
SCHEMBL16026101 0.69 ACHE (0.41) ADORA2AADORA1ACHEADORA3AADAT
SCHEMBL22649179 0.69 SMN1; SMN2 (0.41) ADORA2AADORA1ACHEADORA3AADAT
SCHEMBL31226857 0.69 ADORA2A (0.54) ADORA2AADORA1ACHEADORA3AADAT
SCHEMBL1144980 0.69 NPC1 (0.47) POLBHTT
SCHEMBL15651613 0.68 ADORA2A (0.56) ADORA2AADORA1ACHEADORA3AADAT
SCHEMBL22057946 0.68 ADORA1 (0.39) ADORA2AADORA1ACHEADORA3AADAT
SCHEMBL8230261 0.68 ADORA2A (0.36) ADORA2AADORA1ACHEADORA3AADAT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3888658-B1 EIF4-A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO EFFECTOR THERAPEUTICS INC (US) 2023-12-27 EP disclosed
US-20230295179-A1 EIF4A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO EFFECTOR THERAPEUTICS, INC. 2023-09-21 US disclosed
US-20230295179-A1 EIF4A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO EFFECTOR THERAPEUTICS, INC. 2023-09-21 US disclosed
US-20230295179-A1 EIF4A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO EFFECTOR THERAPEUTICS, INC. 2023-09-21 US disclosed
US-20230071483-A1 EIF4A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO OXFORD FINANCE LLC, AS COLLATERAL AGENT 2023-03-09 US disclosed
US-20230071483-A1 EIF4A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO OXFORD FINANCE LLC, AS COLLATERAL AGENT 2023-03-09 US disclosed
US-11440917-B2 EIF4A-inhibiting compounds and methods related thereto EFFECTOR THERAPEUTICS, INC. (US) 2022-09-13 US disclosed
CN-108601788-B EIF 4A-inhibiting compounds and methods relating thereto 效应治疗股份有限公司 2021-10-22 CN disclosed
EP-3888658-A1 EIF4-A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO Effector Therapeutics Inc. (US) 2021-10-06 EP disclosed
EP-3888658-A1 EIF4-A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO Effector Therapeutics Inc. (US) 2021-10-06 EP disclosed
WO-2017091585-A1 EIF4-A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO EFFECTOR THERAPEUTICS, INC. (US) 2017-06-01 WO disclosed
WO-2017091585-A1 EIF4-A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO EFFECTOR THERAPEUTICS, INC. (US) 2017-06-01 WO disclosed
US-20170145026-A1 EIF4A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO EFFECTOR THERAPEUTICS, INC. 2017-05-25 US disclosed
US-20170145026-A1 EIF4A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO EFFECTOR THERAPEUTICS, INC. 2017-05-25 US disclosed
US-20170145026-A1 EIF4A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO EFFECTOR THERAPEUTICS, INC. 2017-05-25 US disclosed
EP-2297163-B1 Pyrazolospiroketone acetyl-CoA carboxylase inhibitors PFIZER (US) 2015-07-08 EP disclosed
US-8318762-B2 Pyrazolospiroketone acetyl-CoA carboxylase inhibitors PFIZER INC. (US) 2012-11-27 US disclosed
EP-2297163-A1 PYRAZOLOSPIROKETONE ACETYL-C0A CARBOXYLASE INHIBITORS Pfizer Inc. (US) 2011-03-23 EP disclosed
US-20110028390-A1 Pyrazolospiroketone Acetyl-CoA Carboxylase Inhibitors PFIZER, INC. (US) 2011-02-03 US disclosed
WO-2009144554-A1 PYRAZOLOSPIROKETONE ACETYL-C0A CARBOXYLASE INHIBITORS PFIZER, INC. (US) 2009-12-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230295179-A1 EIF4A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO EIF4A1, EIF4A2, EIF4A3 ADORA2A 3648/4885ADORA1 3350/4885ACHE 4751/4885
US-20230071483-A1 EIF4A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO EIF4A1, EIF4A2, EIF4A3 ADORA2A 3648/4885ADORA1 3350/4885ACHE 4751/4885
US-11440917-B2 EIF4A-inhibiting compounds and methods related thereto EIF4A1, EIF4A2, EIF4A3 ADORA2A 3648/4885ADORA1 3350/4885ACHE 4751/4885
US-20110028390-A1 Pyrazolospiroketone Acetyl-CoA Carboxylase Inhibitors ACACA, PC, ACACB ADORA2A 3959/4885ADORA1 2488/4885ACHE 1167/4885
US-20170145026-A1 EIF4A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO EIF4A1, EIF4A2, EIF4A3 ADORA2A 3648/4885ADORA1 3350/4885ACHE 4751/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.