Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 2/20 | 0.56 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.56 |
| ▸ | EIF4A3 | P38919 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | APEX1 | P27695 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1144612 | 0.94 | EIF4A3 (0.60) | SRD5A2SRD5A1EIF4A3KDM4EHPGD | |
| SCHEMBL335983 | 0.87 | SRD5A1 (0.70) | SRD5A2SRD5A1EIF4A3KDM4EHPGD | |
| SCHEMBL3361096 | 0.83 | GPR35 (0.67) | SRD5A2SRD5A1EIF4A3KDM4EHPGD | |
| SCHEMBL30779684 | 0.83 | GPR35 (0.67) | SRD5A2SRD5A1EIF4A3KDM4EHPGD | |
| SCHEMBL3100380 | 0.83 | SRD5A2 (0.58) | SRD5A2SRD5A1EIF4A3KDM4EHPGD | |
| SCHEMBL23389139 | 0.82 | EIF4A3 (0.50) | SRD5A2SRD5A1EIF4A3KDM4EHPGD | |
| SCHEMBL30068484 | 0.82 | EIF4A3 (0.50) | SRD5A2SRD5A1EIF4A3KDM4EHPGD | |
| SCHEMBL6877620 | 0.81 | KMT2A (0.41) | SRD5A2SRD5A1EIF4A3KDM4EHPGD | |
| SCHEMBL7086766 | 0.81 | KDM4E (0.60) | SRD5A2SRD5A1KDM4EHPGDLMNA | |
| SCHEMBL1822934 | 0.81 | EIF4A3 (0.68) | SRD5A2EIF4A3KDM4EHPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297163-B1 | Pyrazolospiroketone acetyl-CoA carboxylase inhibitors | PFIZER (US) | 2015-07-08 | — | — | EP | disclosed |
| US-8318762-B2 | Pyrazolospiroketone acetyl-CoA carboxylase inhibitors | PFIZER INC. (US) | 2012-11-27 | — | — | US | disclosed |
| US-20110028390-A1 | Pyrazolospiroketone Acetyl-CoA Carboxylase Inhibitors | PFIZER, INC. (US) | 2011-02-03 | — | — | US | disclosed |
| WO-2010101127-A1 | INDOLE COMPOUND | アステラス製薬株式会社 (JP) | 2010-09-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028390-A1 | Pyrazolospiroketone Acetyl-CoA Carboxylase Inhibitors | ACACA, PC, ACACB | SRD5A2 435/4885SRD5A1 279/4885EIF4A3 1192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.