Sugi Predict

Sugi Predict / Compounds / SCHEMBL114532

SCHEMBL114532

SCHEMBL114532

Cc1nc(Cl)c(C=O)c(Cl)n1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 4/20 0.40
▸ KDM4E B2RXH2 3/20 0.40
▸ NPSR1 Q6W5P4 3/20 0.40
▸ RECQL P46063 1/20 0.40
▸ RAB9A P51151 1/20 0.37
▸ LMNA P02545 3/20 0.36
▸ CYP1A2 P05177 1/20 0.35
▸ CYP3A4 P08684 1/20 0.35
▸ CYP2D6 P10635 1/20 0.35
▸ CYP2C19 P33261 1/20 0.35
▸ ALDH1A1 P00352 4/20 0.33
▸ MEN1 O00255 3/20 0.33
▸ KMT2A Q03164 3/20 0.33
▸ TDP1 Q9NUW8 2/20 0.33
▸ MPI P34949 1/20 0.33
▸ SMN1; SMN2 Q16637 1/20 0.33
▸ ERN1 O75460 1/20 0.33
▸ PDK2 Q15119 2/20 0.32
▸ PDK4 Q16654 1/20 0.32
▸ CA1 P00915 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29698777 0.86 LMNA (0.40) MAPTKDM4ENPSR1RECQLRAB9A
SCHEMBL24096383 0.86 LMNA (0.40) MAPTKDM4ENPSR1RECQLRAB9A
SCHEMBL31582903 0.81 LMNA (0.38) MAPTKDM4ENPSR1RECQLRAB9A
SCHEMBL23326581 0.81 CA1 (0.34) MAPTKDM4ENPSR1RECQLRAB9A
SCHEMBL55347 0.78 ALDH1A1 (0.39) MAPTKDM4ENPSR1RECQLRAB9A
SCHEMBL30122308 0.77 CA1 (0.32) MAPTKDM4ENPSR1RECQLCA1
SCHEMBL192661 0.76 LMNA (0.55) MAPTKDM4ENPSR1RECQLRAB9A
SCHEMBL6066162 0.74 LMNA (0.36) MAPTKDM4ENPSR1RECQLRAB9A
SCHEMBL25265565 0.74 PDK2 (0.32) TDP1PDK2PDK4
SCHEMBL11338618 0.74 LMNA (0.36) MAPTKDM4ENPSR1RECQLRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 116 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116217493-A Preparation method of 4, 6-dichloro-2-methyl-5-pyrimidine formaldehyde 郑州猫眼农业科技有限公司 2023-06-06 — — CN claimed
WO-2025264818-A1 STAT6 MODULATORS AND METHODS OF USES THEREOF RAYTHERA, INC. (US) 2025-12-26 — — WO disclosed
US-12492183-B2 Tetrahydroquinazoline derivatives as selective cytotoxic agents MERCK SHARP & DOHME LLC (US) 2025-12-09 — — US disclosed
US-20250340565-A1 CD73 INHIBITOR COMPOUNDS ADORX THERAPEUTICS LTD (GB) 2025-11-06 — — US disclosed
US-20250230159-A1 FUSED HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAS SIGNALLING SHENZHEN IONOVA LIFE SCIENCE CO., LTD. (CN) 2025-07-17 — — US disclosed
WO-2025106780-A1 RXFP1 RECEPTOR AGONISTS ELI LILLY AND COMPANY (US) 2025-05-22 — — WO disclosed
CN-116265462-B Heterocyclic compound with antitumor activity and application thereof 石药集团中奇制药技术（石家庄）有限公司 2025-05-16 — — CN disclosed
EP-4532495-A1 CD73 INHIBITOR COMPOUNDS Adorx therapeutics Limited (GB) 2025-04-09 — — EP disclosed
US-12258329-B2 Pyrimidone derivatives as selective cytotoxic agents against HIV infected cells MERCK SHARP & DOHME LLC (US) 2025-03-25 — — US disclosed
CN-119585273-A CD73 inhibitor compounds 阿道尔克斯治疗有限公司 2025-03-07 — — CN disclosed
US-20110251173-A1 CHEMICAL COMPOUNDS ASTRAZENECA AB (SE) 2011-10-13 — — US disclosed
US-20110251173-A1 CHEMICAL COMPOUNDS ASTRAZENECA AB (SE) 2011-10-13 — — US disclosed
US-20110251173-A1 CHEMICAL COMPOUNDS ASTRAZENECA AB (SE) 2011-10-13 — — US disclosed
WO-2011121350-A1 4 -AMINO -7,8- DIHYDROPYRIMIDO [5, 4 - F] [1, 4] OXAZEPIN- 5 ( 6H) - ONE BASED DGAT1 INHIBITORS ASTRAZENECA AB (SE) 2011-10-06 — — WO disclosed
WO-2011121350-A1 4 -AMINO -7,8- DIHYDROPYRIMIDO [5, 4 - F] [1, 4] OXAZEPIN- 5 ( 6H) - ONE BASED DGAT1 INHIBITORS ASTRAZENECA AB (SE) 2011-10-06 — — WO disclosed
WO-2010132598-A1 HETEROARYL COMPOUNDS AS PIKK INHIBITORS AMGEN INC. (US) 2010-11-18 — — WO disclosed
WO-2010126895-A1 INHIBITORS OF PI3 KINASE AND / OR MTOR AMGEN INC. (US) 2010-11-04 — — WO disclosed
US-20100273764-A1 INHIBITORS OF PI3 KINASE AND/OR MTOR AMGEN INC. (US) 2010-10-28 — — US disclosed
US-4952679-A PRINTING, DYEING CELLULOSE CIBA-GEIGY CORPORATION (US) 1990-08-28 — — US disclosed
EP-0304926-A2 Reactive dyes, their preparation and their use CIBA-GEIGY AG (CH) 1989-03-01 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12492183-B2 Tetrahydroquinazoline derivatives as selective cytotoxic agents ACIN1, CD4, NFATC1 MAPT 2168/4885KDM4E 3846/4885NPSR1 4717/4885
US-20100273764-A1 INHIBITORS OF PI3 KINASE AND/OR MTOR MTOR, PIK3CA, PIK3CD MAPT 1510/4885KDM4E 1916/4885NPSR1 4196/4885
US-20250340565-A1 CD73 INHIBITOR COMPOUNDS ENTPD5, ENTPD1, NT5E MAPT 4537/4885KDM4E 1094/4885NPSR1 1497/4885
US-12258329-B2 Pyrimidone derivatives as selective cytotoxic agents against HIV infected cells TYMP, PNP, CD4 MAPT 1869/4885KDM4E 3098/4885NPSR1 3727/4885
US-20110251173-A1 CHEMICAL COMPOUNDS DGAT1, DGAT2, SLC5A1 MAPT 1269/4885KDM4E 4123/4885NPSR1 830/4885
US-20250230159-A1 FUSED HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAS SIGNALLING KRAS, HRAS, NRAS MAPT 532/4885KDM4E 4217/4885NPSR1 3107/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.