SCHEMBL11459461

SCHEMBL11459461

CC(C)(O)C#Cc1ccc([N+](=O)[O-])cc1[N+](=O)[O-]

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.47
GPR35 Q9HC97 3/20 0.47
MAPK1 P28482 2/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
TSHR P16473 2/20 0.47
TP53 P04637 1/20 0.47
HPGD P15428 1/20 0.47
TDP1 Q9NUW8 4/20 0.45
HIF1A Q16665 1/20 0.44
TXNRD1 Q16881 1/20 0.42
TXNRD3 Q86VQ6 1/20 0.42
TXNRD2 Q9NNW7 1/20 0.42
MAPT P10636 5/20 0.41
HTT P42858 3/20 0.41
KMT2A Q03164 2/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
CYP1A2 P05177 1/20 0.41
MEN1 O00255 1/20 0.39
CES2 O00748 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11443594 0.85 MAPT (0.41) ALDH1A1GPR35SMN1; SMN2MAPTHTT
SCHEMBL28850334 0.84 CYP3A4 (0.49) ALDH1A1GPR35SMN1; SMN2TSHRTDP1
SCHEMBL11452376 0.80 HSD17B10 (0.43) ALDH1A1GPR35SMN1; SMN2TSHRHPGD
SCHEMBL11450427 0.78 CASP6 (0.42) ALDH1A1GPR35MAPK1SMN1; SMN2TSHR
SCHEMBL7911029 0.76 ALDH1A1 (0.61) ALDH1A1MAPK1SMN1; SMN2HPGDTDP1
SCHEMBL18707834 0.75 ALDH1A1 (0.41) ALDH1A1GPR35MAPK1SMN1; SMN2TSHR
SCHEMBL5079763 0.75 TDP1 (0.59) ALDH1A1GPR35MAPK1SMN1; SMN2TSHR
SCHEMBL845167 0.74 ALDH1A1 (0.54) ALDH1A1SMN1; SMN2TSHRTP53TDP1
SCHEMBL1795352 0.73 TDP1 (0.57) ALDH1A1GPR35MAPK1SMN1; SMN2TSHR
SCHEMBL15957599 0.73 DRD5 (0.44) ALDH1A1GPR35TSHRTDP1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023048034-A1 METHOD FOR PRODUCING AROMATIC COMPOUND HAVING ETHYNYL GROUP 東レ・ファインケミカル株式会社 2023-03-30 WO disclosed
WO-2023008401-A1 METHOD FOR PRODUCING AROMATIC COMPOUND HAVING ETHYNYL GROUP 東レ・ファインケミカル株式会社 2023-02-02 WO disclosed
US-4219679-A HIGH CONVERSION GULF RESEARCH & DEVELOPMENT COMPANY (US) 1980-08-26 US disclosed
US-4216341-A Selective hydrogenation of certain nitroaromatic hydroxy substituted acetylenes over a heterogeneous RuS2 catalyst GULF RESEARCH & DEVELOPMENT COMPANY (US) 1980-08-05 US disclosed
US-4139561-A RUTHENIUM HYDROGENATION CATALYST GULF RESEARCH & DEVELOPMENT COMPANY (US) 1979-02-13 US disclosed