Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | NAAA | Q02083 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | FPR3 | P25089 | 1/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | SPHK1 | Q9NYA1 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11468097 | 0.86 | SIGMAR1 (0.52) | EPHX1SIGMAR1CYP2D6FPR3FPR2 | |
| SCHEMBL11477579 | 0.83 | FPR3 (0.46) | EPHX1SIGMAR1CYP2D6CA12CA1 | |
| SCHEMBL1050014 | 0.70 | TDP1 (0.78) | EPHX1CYP2D6CA12CA1CA2 | |
| SCHEMBL2285048 | 0.70 | TDP1 (0.78) | EPHX1CYP2D6CA12CA1CA2 | |
| SCHEMBL6255210 | 0.69 | SIGMAR1 (0.55) | EPHX1SIGMAR1NAAASPHK1METAP2 | |
| SCHEMBL16570238 | 0.69 | SIGMAR1 (0.55) | EPHX1SIGMAR1NAAASPHK1METAP2 | |
| SCHEMBL17172545 | 0.69 | NAAA (0.82) | EPHX1NAAAKEAP1NFE2L2 | |
| SCHEMBL7296108 | 0.68 | TDP1 (0.82) | EPHX1CYP2D6CA12CA1CA2 | |
| SCHEMBL11502078 | 0.67 | ALDH1A1 (0.36) | EPHX1SIGMAR1NAAASPHK1 | |
| SCHEMBL7776473 | 0.66 | EPHX1 (0.73) | EPHX1CYP2D6CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4115447-A | Carbamylguanidine antimicrobial compounds | COOPER LABORATORIES, INC. (US) | 1978-09-19 | — | — | US | claimed |
| US-4209624-A | Process for preparing substituted bis(amidinoureas) | COOPER LABORATORIES, INC. (US) | 1980-06-24 | — | — | US | disclosed |