Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | TOP1 | P11387 | 1/20 | 0.44 |
| ▸ | TOP2A | P11388 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8381483 | 0.90 | TOP1 (0.51) | KDM4ECD274LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL11455003 | 0.85 | KDM4E (0.41) | KDM4ECD274LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL11447099 | 0.83 | HTR7 (0.52) | KMT2ASMN1; SMN2POLB | |
| SCHEMBL11465420 | 0.83 | ALDH1A1 (0.66) | KDM4ECD274KMT2AALDH1A1HTT | |
| SCHEMBL11446241 | 0.83 | GAA (0.46) | KDM4EKMT2AALDH1A1CSF1RHTT | |
| Hydrochloric Acid SCHEMBL11447560 | 0.82 | HTR7 (0.51) | KMT2ASMN1; SMN2POLB | |
| SCHEMBL20607642 | 0.80 | ALDH1A1 (0.56) | CD274LMNAKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL2463879 | 0.80 | KDM4E (0.58) | KDM4ECD274ALDH1A1PARP1AR | |
| SCHEMBL11454661 | 0.79 | CARM1 (0.49) | — | |
| SCHEMBL15557738 | 0.79 | ALDH1A1 (0.49) | KDM4ECD274LMNAKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4205173-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1980-05-27 | — | — | US | disclosed |
| US-4085107-A | ANALGESICS | PENNWALT CORPORATION (US) | 1978-04-18 | — | — | US | disclosed |
| US-4060526-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1977-11-29 | — | — | US | disclosed |