Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | AR | P10275 | 1/20 | 0.48 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11465420 | 0.83 | ALDH1A1 (0.66) | KDM4EALDH1A1CD274POLBHPGD | |
| SCHEMBL3222256 | 0.80 | EPHX2 (0.54) | KDM4EALDH1A1CD274POLBHTR1A | |
| SCHEMBL11465072 | 0.80 | KDM4E (0.50) | KDM4EALDH1A1ARCD274POLB | |
| SCHEMBL3230823 | 0.79 | HTR7 (0.63) | KDM4EALDH1A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL27516593 | 0.78 | KDM4E (0.46) | KDM4EALDH1A1ARCD274POLB | |
| SCHEMBL4524250 | 0.76 | KDM4E (0.63) | KDM4EALDH1A1POLBPARP1 | |
| SCHEMBL23286940 | 0.75 | ALDH1A1 (0.54) | KDM4EALDH1A1CD274POLBCYP2C19 | |
| SCHEMBL3770520 | 0.75 | LMNA (0.74) | KDM4EALDH1A1CD274POLBCYP1A2 | |
| SCHEMBL12513990 | 0.74 | SMN1; SMN2 (0.55) | KDM4EALDH1A1CD274HTR1AMAOA | |
| SCHEMBL30216224 | 0.74 | KDM4E (1.00) | KDM4EALDH1A1ARPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8012956-B2 | Tropane compounds | EXELIXIS, INC. (US) | 2011-09-06 | — | — | US | claimed |
| US-20090163471-A1 | Tropane compounds | EXELIXIS, INC. | 2009-06-25 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163471-A1 | Tropane compounds | ADRA1B, ADRA2B, ADRB2 | KDM4E 4402/4885ALDH1A1 323/4885AR 361/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.