Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | PNP | P00491 | 3/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.43 |
| ▸ | CDK1 | P06493 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.41 |
| ▸ | YTHDC1 | Q96MU7 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | PI4KA | P42356 | 1/20 | 0.41 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.41 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1146640 | 0.83 | PNP (0.40) | PDE4APDE4BPDE4CPDE4DPNP | |
| SCHEMBL1146545 | 0.80 | YTHDC1 (0.53) | PDE4APDE4BPDE4CPDE4DPNP | |
| SCHEMBL5464136 | 0.74 | TLR7 (0.47) | PDE4APDE4BPDE4CPDE4DPNP | |
| SCHEMBL19539671 | 0.71 | YTHDC1 (0.63) | HDAC6HDAC1HDAC4CDK1HDAC2 | |
| SCHEMBL2060294 | 0.71 | ALDH1A1 (0.47) | ADORA2A | |
| SCHEMBL19539867 | 0.70 | YTHDC1 (0.74) | HDAC6HDAC1HDAC4HDAC2YTHDC1 | |
| SCHEMBL5161756 | 0.70 | CDK1 (0.73) | PDE4APDE4BPDE4CPDE4DCDK1 | |
| SCHEMBL2060324 | 0.68 | TLR7 (0.51) | ADORA2A | |
| SCHEMBL19539318 | 0.68 | YTHDC1 (0.61) | HDAC6HDAC1HDAC4HDAC2YTHDC1 | |
| SCHEMBL1146681 | 0.68 | YTHDC1 (0.67) | PDE4APDE4BPDE4CPDE4DHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110028715-A1 | NOVEL ADENINE COMPOUND | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2011-02-03 | — | — | US | disclosed |
| US-20110028715-A1 | NOVEL ADENINE COMPOUND | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2011-02-03 | — | — | US | disclosed |
| US-20100093998-A1 | NOVEL ADENINE COMPOUND | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2010-04-15 | — | — | US | disclosed |
| US-20100093998-A1 | NOVEL ADENINE COMPOUND | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2010-04-15 | — | — | US | disclosed |
| CN-101679433-A | Novel adenine compound | DAINIPPON SUMITOMO PHARMA CO | 2010-03-24 | — | — | CN | disclosed |
| EP-2133353-A1 | NOVEL ADENINE COMPOUND | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2009-12-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028715-A1 | NOVEL ADENINE COMPOUND | NR0B2, NR0B1, BRD7 | PDE4A 3469/4885PDE4B 3371/4885PDE4C 3465/4885 |
| US-20100093998-A1 | NOVEL ADENINE COMPOUND | NR0B2, NR0B1, BRD7 | PDE4A 3468/4885PDE4B 3334/4885PDE4C 3457/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.