Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 7/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.42 |
| ▸ | NPC1 | O15118 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | ACACA | Q13085 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11485886 | 0.90 | PTGES (0.47) | PTGESRAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL11232062 | 0.82 | NPSR1 (0.55) | PTGESRAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL11469057 | 0.81 | PTGES (0.55) | PTGESRAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL11483239 | 0.80 | PTGES (0.61) | PTGESRAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL11467226 | 0.80 | NPSR1 (0.47) | PTGESRAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL11466969 | 0.79 | MAPT (0.54) | PTGESRAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL11466676 | 0.77 | PTGES (0.40) | PTGESNPC1TP53MAPTLMNA | |
| SCHEMBL11865062 | 0.76 | RAB9A (0.46) | RAB9ASMN1; SMN2NPC1KDM4EL3MBTL1 | |
| SCHEMBL11483171 | 0.75 | RAB9A (0.49) | RAB9ASMN1; SMN2NPC1KDM4EL3MBTL1 | |
| SCHEMBL11468034 | 0.74 | RAB9A (0.41) | RAB9ASMN1; SMN2NPC1KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4190725-A | ANTIINFLAMMATORY | ELI LILLY AND COMPANY (US) | 1980-02-26 | — | — | US | disclosed |
| US-4021553-A | 5,6-Diaryl-1,2,4-triazines as topically-active anti-inflammatory agents | ELI LILLY AND COMPANY (US) | 1977-05-03 | — | — | US | disclosed |