Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | PTGES | O14684 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11232062 | 0.91 | NPSR1 (0.55) | NPSR1PTGESSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL11243005 | 0.88 | NPSR1 (0.58) | NPSR1PTGESSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL11485886 | 0.82 | PTGES (0.47) | PTGESSMN1; SMN2MAPTALDH1A1RAB9A | |
| SCHEMBL11478727 | 0.81 | LMNA (0.48) | NPSR1PTGESMAPTALDH1A1LMNA | |
| SCHEMBL11477773 | 0.80 | NPSR1 (0.58) | NPSR1PTGESSMN1; SMN2MAPTRAB9A | |
| SCHEMBL11468314 | 0.80 | PTGES (0.45) | PTGESSMN1; SMN2MAPTALDH1A1RAB9A | |
| SCHEMBL11469057 | 0.79 | PTGES (0.55) | PTGESSMN1; SMN2MAPTALDH1A1RAB9A | |
| SCHEMBL11483239 | 0.78 | PTGES (0.61) | PTGESSMN1; SMN2MAPTALDH1A1RAB9A | |
| SCHEMBL11479740 | 0.77 | PTGES (0.73) | PTGESMAPTLMNA | |
| SCHEMBL11240284 | 0.76 | PTGES (0.57) | NPSR1PTGESSMN1; SMN2MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4190725-A | ANTIINFLAMMATORY | ELI LILLY AND COMPANY (US) | 1980-02-26 | — | — | US | disclosed |
| US-4021553-A | 5,6-Diaryl-1,2,4-triazines as topically-active anti-inflammatory agents | ELI LILLY AND COMPANY (US) | 1977-05-03 | — | — | US | disclosed |