Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.33 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11484230 | 0.81 | SRC (0.35) | PTGS1 | |
| SCHEMBL11231697 | 0.79 | KDM4E (0.39) | WDR5KDM4EALDH1A1MAPTADORA2A | |
| SCHEMBL11471160 | 0.78 | LMNA (0.51) | ALDH1A1MAPTNPSR1TNK2NPC1 | |
| SCHEMBL11477775 | 0.75 | WDR5 (0.36) | WDR5KDM4EALDH1A1MAPTPOLB | |
| SCHEMBL11467215 | 0.75 | SCN9A (0.40) | WDR5ALDH1A1MAPTADORA2AADORA1 | |
| SCHEMBL11468262 | 0.73 | LMNA (0.47) | KDM4EALDH1A1MAPTRECQLNPSR1 | |
| SCHEMBL11245322 | 0.73 | ALDH1A1 (0.46) | KDM4EALDH1A1MAPTADORA2AADORA1 | |
| SCHEMBL11470501 | 0.72 | MAPT (0.40) | WDR5ALDH1A1MAPTADORA2AADORA1 | |
| SCHEMBL11243005 | 0.72 | NPSR1 (0.58) | WDR5KDM4EALDH1A1MAPTPOLB | |
| SCHEMBL11873100 | 0.71 | MAP4K4 (0.40) | WDR5MAPTADORA2AADORA1ALDH1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4190725-A | ANTIINFLAMMATORY | ELI LILLY AND COMPANY (US) | 1980-02-26 | — | — | US | disclosed |
| US-4021553-A | 5,6-Diaryl-1,2,4-triazines as topically-active anti-inflammatory agents | ELI LILLY AND COMPANY (US) | 1977-05-03 | — | — | US | disclosed |