Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | PDXK | O00764 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.36 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.35 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4016022 | 0.87 | KDM4E (0.61) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Hydrochloric Acid SCHEMBL11450069 | 0.86 | PDXK (0.46) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL14899351 | 0.83 | LMNA (0.65) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL1645737 | 0.80 | PDXK (0.56) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL11457370 | 0.79 | HPGD (0.76) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Hydrochloric Acid SCHEMBL11468666 | 0.77 | KDM4E (0.73) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL3761208 | 0.74 | PDXK (0.62) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL29638818 | 0.74 | PDXK (0.62) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Hydrochloric Acid SCHEMBL11700751 | 0.72 | ALDH1A1 (0.60) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL5331328 | 0.71 | GAA (0.45) | KDM4EALDH1A1HPGDHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4212976-A | ANTIARTHRITIC AGENTS | MERCK & CO., INC. (US) | 1980-07-15 | — | — | US | disclosed |
| US-4057637-A | RHEUMATOID ARTHRITIS | MERCK & CO., INC. (US) | 1977-11-08 | — | — | US | disclosed |
| US-3971797-A | ANTIARTHRITIC | MERCK & CO., INC. (US) | 1976-07-27 | — | — | US | disclosed |