SCHEMBL11469366

SCHEMBL11469366

CN(C)c1cccc(NN)c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.48
TSHR P16473 1/20 0.48
KDM1A O60341 1/20 0.47
MAPT P10636 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
NOS1 P29475 2/20 0.44
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
GAA P10253 1/20 0.44
ALOX15 P16050 1/20 0.44
MAPK1 P28482 1/20 0.43
BCHE P06276 1/20 0.42
ACHE P22303 1/20 0.42
LMNA P02545 1/20 0.42
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2D6 P10635 1/20 0.42
CYP2C9 P11712 1/20 0.42
IDO1 P14902 1/20 0.42
CYP2C19 P33261 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL3186220 0.98 ALDH1A1 (0.47) ALDH1A1TSHRKDM1AMAPTSMN1; SMN2
Hydrochloric Acid SCHEMBL3178540 0.98 ALDH1A1 (0.47) ALDH1A1TSHRKDM1AMAPTSMN1; SMN2
SCHEMBL3030672 0.82 KDM1A (0.59) ALDH1A1TSHRKDM1AMAPTSMN1; SMN2
SCHEMBL31726567 0.80 ALDH1A1 (0.50) ALDH1A1TSHRKDM1AMAPTSMN1; SMN2
SCHEMBL1268756 0.80 ALDH1A1 (0.50) ALDH1A1TSHRKDM1AMAPTSMN1; SMN2
Hydrochloric Acid SCHEMBL11291701 0.78 ALDH1A1 (0.48) ALDH1A1TSHRKDM1AMAPTSMN1; SMN2
SCHEMBL10089591 0.78 ALDH1A1 (0.48) ALDH1A1TSHRKDM1AMAPTSMN1; SMN2
SCHEMBL7655949 0.78 ALDH1A1 (0.53) ALDH1A1TSHRMAPTSMN1; SMN2NOS1
SCHEMBL28557487 0.77 KDM1A (0.63) ALDH1A1TSHRKDM1AMAPTMEN1
SCHEMBL219895 0.75 TDP1 (0.61) ALDH1A1MAPTNOS1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4226774-A Carbazole melonates HOFFMANN-LA ROCHE INC. (US) 1980-10-07 US disclosed
US-4193923-A Tetrahydro 2-carbazolyl methyl malonate derivatives HOFFMANN-LA ROCHE INC. (US) 1980-03-18 US disclosed
US-4158007-A Carbazole methyl malonates HOFFMANN-LA ROCHE INC. (US) 1979-06-12 US disclosed