Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 4/20 | 0.62 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11483239 | 0.90 | PTGES (0.61) | PTGESMAPTLMNATP53PTGS2 | |
| SCHEMBL11485827 | 0.89 | PTGES (0.79) | PTGESMAPTLMNATP53PTGS2 | |
| SCHEMBL11476250 | 0.88 | MAPT (0.59) | PTGESMAPTLMNATP53PTGS2 | |
| SCHEMBL11244831 | 0.87 | PTGES (0.80) | PTGESMAPTLMNATP53PTGS2 | |
| SCHEMBL11468271 | 0.84 | PTGES (0.52) | PTGESMAPTLMNATP53PTGS2 | |
| SCHEMBL11477773 | 0.84 | NPSR1 (0.58) | PTGESMAPTLMNATP53NPC1 | |
| SCHEMBL11472297 | 0.82 | LMNA (0.58) | PTGESMAPTLMNATP53PTGS2 | |
| SCHEMBL11466969 | 0.80 | MAPT (0.54) | PTGESMAPTLMNATP53PTGS2 | |
| SCHEMBL11469057 | 0.80 | PTGES (0.55) | PTGESMAPTLMNATP53PTGS2 | |
| SCHEMBL11240834 | 0.79 | PTGES (0.90) | PTGESMAPTLMNATP53PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4190725-A | ANTIINFLAMMATORY | ELI LILLY AND COMPANY (US) | 1980-02-26 | — | — | US | disclosed |
| US-4021553-A | 5,6-Diaryl-1,2,4-triazines as topically-active anti-inflammatory agents | ELI LILLY AND COMPANY (US) | 1977-05-03 | — | — | US | disclosed |