Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.67 |
| ▸ | PTGES | O14684 | 3/20 | 0.62 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11468338 | 0.88 | PTGES (0.53) | GPR84PTGESCASP3SENP8SENP7 | |
| SCHEMBL11470583 | 0.87 | GPR84 (0.65) | GPR84PTGESCASP3SENP8SENP7 | |
| SCHEMBL11482987 | 0.85 | GPR84 (0.62) | GPR84PTGESCASP3SENP8SENP7 | |
| SCHEMBL11231246 | 0.82 | GPR84 (0.54) | GPR84PTGESALDH1A1HPGDKDM4E | |
| Hydrochloric Acid SCHEMBL9695495 | 0.79 | MAOB (0.53) | GPR84PTGESALDH1A1KDM4ELMNA | |
| SCHEMBL11466785 | 0.79 | PTGES (0.61) | GPR84PTGESCASP3SENP8SENP7 | |
| SCHEMBL11477119 | 0.77 | PTGES (1.00) | PTGESMAPT | |
| SCHEMBL1306904 | 0.77 | PTGES (0.58) | PTGESCASP3SENP8SENP7SENP6 | |
| SCHEMBL28827857 | 0.76 | CASP3 (0.51) | PTGESCASP3SENP8SENP7SENP6 | |
| Hydrochloric Acid SCHEMBL9695587 | 0.76 | GPR84 (0.52) | GPR84PTGESALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4190725-A | ANTIINFLAMMATORY | ELI LILLY AND COMPANY (US) | 1980-02-26 | — | — | US | disclosed |
| US-4021553-A | 5,6-Diaryl-1,2,4-triazines as topically-active anti-inflammatory agents | ELI LILLY AND COMPANY (US) | 1977-05-03 | — | — | US | disclosed |