Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxymorphone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 known ✓ | P41143 | 12/20 | 0.72 |
| ▸ | OPRM1 known ✓ | P35372 | 10/20 | 0.72 |
| ▸ | OPRK1 known ✓ | P41145 | 8/20 | 0.72 |
| ▸ | MRGPRX2 | Q96LB1 | 2/20 | 0.69 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.69 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.69 |
| ▸ | ARRB1 | P49407 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxycodone SCHEMBL1029465 | 0.94 | OPRM1 (0.68) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Oxymorphone SCHEMBL1828172 | 0.94 | OPRM1 (0.68) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Naltrexone SCHEMBL2425204 | 0.92 | OPRM1 (0.71) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Oxymorphone SCHEMBL11805791 | 0.92 | OPRM1 (0.60) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Naloxone SCHEMBL2588324 | 0.91 | OPRK1 (0.71) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Oxycodone SCHEMBL4588570 | 0.91 | OPRM1 (0.73) | OPRD1OPRM1OPRK1MRGPRX2 | |
| Naloxone SCHEMBL28209122 | 0.91 | OPRK1 (0.71) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Oxycodone SCHEMBL19285728 | 0.90 | OPRM1 (0.61) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Oxycodone SCHEMBL17165053 | 0.90 | OPRM1 (0.61) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Naltrexone SCHEMBL29392247 | 0.89 | OPRM1 (0.67) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4233217-A | USED AS ANALGESICS, NARCOTIC ANTAGONISTS, AND ANTIHISTAMINES | PENNWALT CORPORATION (US) | 1980-11-11 | — | — | US | disclosed |
| US-4210749-A | USED AS ANALGESICS, NARCOTIC ANTAGONISTS | PENNWALT CORPORATION (US) | 1980-07-01 | — | — | US | disclosed |