Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxycodone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 11/20 | 0.68 |
| ▸ | OPRD1 | P41143 | 8/20 | 0.68 |
| ▸ | OPRK1 | P41145 | 8/20 | 0.68 |
| ▸ | MRGPRX2 | Q96LB1 | 4/20 | 0.65 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.65 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.65 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.61 |
| ▸ | ARRB1 | P49407 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxymorphone SCHEMBL1828172 | 1.00 | OPRM1 (0.68) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Oxycodone SCHEMBL4588570 | 0.97 | OPRM1 (0.73) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Oxycodone SCHEMBL19285728 | 0.95 | OPRM1 (0.61) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Oxycodone SCHEMBL17165053 | 0.95 | OPRM1 (0.61) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Oxymorphone SCHEMBL11477430 | 0.94 | OPRD1 (0.72) | OPRM1OPRD1OPRK1MRGPRX2SLC22A1 | |
| Oxycodone SCHEMBL19463262 | 0.93 | OPRM1 (0.59) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Nalorphine SCHEMBL19816078 | 0.93 | OPRK1 (0.63) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Naloxone SCHEMBL5657970 | 0.92 | OPRM1 (0.66) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Oxycodone SCHEMBL7570264 | 0.92 | OPRM1 (0.65) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Naltrexone SCHEMBL2425204 | 0.88 | OPRM1 (0.71) | OPRM1OPRD1OPRK1MRGPRX2SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9884029-B2 | Morphine controlled release system | EGALET LTD. (GB) | 2018-02-06 | — | — | US | disclosed |
| US-20160361269-A1 | MORPHINE CONTROLLED RELEASE SYSTEM | EGALET LTD. (GB) | 2016-12-15 | — | — | US | disclosed |
| US-9375428-B2 | Morphine controlled release system | EGALET LTD. (GB) | 2016-06-28 | — | — | US | disclosed |
| EP-2301526-B1 | Morphine controlled release system | EGALET LTD (GB) | 2016-03-23 | — | — | EP | disclosed |
| US-20150079150-A1 | MORPHINE CONTROLLED RELEASE SYSTEM | EGALET LTD. (GB) | 2015-03-19 | — | — | US | disclosed |
| US-8877241-B2 | Morphine controlled release system | EGALET LTD. (GB) | 2014-11-04 | — | — | US | disclosed |
| CN-101106996-B | Use of oxycodone for treating visceral pain | EURO CELTIQUE SA | 2013-10-23 | — | — | CN | disclosed |
| EP-2301526-A2 | Morphine controlled release system | Egalet A/S (DK) | 2011-03-30 | — | — | EP | disclosed |
| EP-1610767-B1 | MORPHINE CONTROLLED RELEASE SYSTEM | EGALET AS (DK) | 2011-01-19 | — | — | EP | disclosed |
| CN-101106996-A | Use of oxycodone for treating visceral pain | EURO CELTIQUE SA (LU) | 2008-01-16 | — | — | CN | disclosed |
| EP-1838318-A1 | USE OF OXYCODONE FOR TREATING VISCERAL PAIN | EURO-CELTIQUE S.A. (LU) | 2007-10-03 | — | — | EP | disclosed |
| US-20070003617-A1 | Morphine controlled release system | EGALET A/S | 2007-01-04 | — | — | US | disclosed |
| WO-2006077212-A1 | USE OF OXYCODONE FOR TREATING VISCERAL PAIN | EURO-CELTIQUE S.A. (LU) | 2006-07-27 | — | — | WO | disclosed |
| EP-1610767-A1 | MORPHINE CONTROLLED RELEASE SYSTEM | Egalet A/S (DK) | 2006-01-04 | — | — | EP | disclosed |
| WO-2004084868-A1 | MORPHINE CONTROLLED RELEASE SYSTEM | EGALET A/S (DK) | 2004-10-07 | — | — | WO | disclosed |
| CN-1501941-A | Chemical compounds | — | 2004-06-02 | — | — | CN | disclosed |