Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Naltrexone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 11/20 | 0.71 |
| ▸ | OPRD1 known ✓ | P41143 | 10/20 | 0.71 |
| ▸ | OPRK1 known ✓ | P41145 | 10/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.71 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.71 |
| ▸ | PKM | P14618 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.69 |
| ▸ | MRGPRX2 | Q96LB1 | 2/20 | 0.61 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.61 |
| ▸ | ARRB1 | P49407 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Naltrexone SCHEMBL29392247 | 0.97 | OPRM1 (0.67) | OPRM1OPRD1OPRK1CYP2D6CHRNA7 | |
| Naltrexone SCHEMBL30313410 | 0.97 | OPRM1 (0.68) | OPRM1OPRD1OPRK1CYP2D6CHRNA7 | |
| Oxymorphone SCHEMBL11477430 | 0.92 | OPRD1 (0.72) | OPRM1OPRD1OPRK1MRGPRX2SLC22A1 | |
| Naltrexone SCHEMBL9837116 | 0.92 | OPRK1 (0.68) | OPRM1OPRD1OPRK1CYP2D6CHRNA7 | |
| Naloxone SCHEMBL2588324 | 0.91 | OPRK1 (0.71) | OPRM1OPRD1OPRK1CYP2D6LMNA | |
| Naloxone SCHEMBL28209122 | 0.91 | OPRK1 (0.71) | OPRM1OPRD1OPRK1CYP2D6LMNA | |
| Naloxone SCHEMBL4950697 | 0.89 | OPRK1 (0.68) | OPRM1OPRD1OPRK1CYP2D6LMNA | |
| Nalmefene SCHEMBL7574800 | 0.88 | OPRK1 (0.64) | OPRM1OPRD1OPRK1CYP2D6CHRNA7 | |
| Oxycodone SCHEMBL1029465 | 0.88 | OPRM1 (0.68) | OPRM1OPRD1OPRK1CYP2D6MRGPRX2 | |
| Oxymorphone SCHEMBL1828172 | 0.88 | OPRM1 (0.68) | OPRM1OPRD1OPRK1CYP2D6MRGPRX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549984-B1 | DOUBLE-LAYER PHARMACEUTICAL FORMULATIONS CONTAINING OPIOID AGONISTS AND ANTAGONISTS | MOLTENI & C (IT) | 2015-03-18 | — | — | EP | disclosed |
| EP-2549984-A1 | DOUBLE-LAYER PHARMACEUTICAL FORMULATIONS CONTAINING OPIOID AGONISTS AND ANTAGONISTS | Molteni L. E C. Dei Fratelli Alitti Societa' Di Esercizio S.P.A. (IT) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011117306-A1 | DOUBLE-LAYER PHARMACEUTICAL FORMULATIONS CONTAINING OPIOID AGONISTS AND ANTAGONISTS | L. MOLTENI & C. DEI FRATELLI ALITTI SOCIETA' DI ESERCIZIO S.P.A. (IT) | 2011-09-29 | — | — | WO | disclosed |
| US-6153621-A | Combined antagonist compositions | THE UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2000-11-28 | — | — | US | disclosed |
| WO-1996019219-A1 | METHOD FOR TREATING OPIATE WITHDRAWAL | SPECTOR SYDNEY (US) | 1996-06-27 | — | — | WO | disclosed |