Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxymorphone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 11/20 | 0.68 |
| ▸ | OPRD1 known ✓ | P41143 | 8/20 | 0.68 |
| ▸ | OPRK1 known ✓ | P41145 | 8/20 | 0.68 |
| ▸ | MRGPRX2 | Q96LB1 | 4/20 | 0.65 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.65 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.65 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.61 |
| ▸ | ARRB1 | P49407 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxycodone SCHEMBL1029465 | 1.00 | OPRM1 (0.68) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Oxycodone SCHEMBL4588570 | 0.97 | OPRM1 (0.73) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Oxycodone SCHEMBL19285728 | 0.95 | OPRM1 (0.61) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Oxycodone SCHEMBL17165053 | 0.95 | OPRM1 (0.61) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Oxymorphone SCHEMBL11477430 | 0.94 | OPRD1 (0.72) | OPRM1OPRD1OPRK1MRGPRX2SLC22A1 | |
| Oxycodone SCHEMBL19463262 | 0.93 | OPRM1 (0.59) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Nalorphine SCHEMBL19816078 | 0.93 | OPRK1 (0.63) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Naloxone SCHEMBL5657970 | 0.92 | OPRM1 (0.66) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Oxycodone SCHEMBL7570264 | 0.92 | OPRM1 (0.65) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Naltrexone SCHEMBL2425204 | 0.88 | OPRM1 (0.71) | OPRM1OPRD1OPRK1MRGPRX2SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037885-B1 | LOW DOSE SUBLINGUAL TABLETS OF OPIOID ANALGESICS AND PREPARATION PROCESS | ETHYPHARM SA (FR) | 2015-01-21 | — | — | EP | claimed |
| EP-1858491-B1 | SUBLINGUAL COATED TABLET | ETHYPHARM SA (FR) | 2011-05-04 | — | — | EP | claimed |
| US-20100233257-A1 | LOW DOSE SUBLINGUAL TABLETS OF OPIOID ANALGESICS AND PREPARATION PROCESS | ETHYPHARM (FR) | 2010-09-16 | — | — | US | claimed |
| EP-2037885-A1 | LOW DOSE SUBLINGUAL TABLETS OF OPIOID ANALGESICS AND PREPARATION PROCESS | ETHYPHARM (FR) | 2009-03-25 | — | — | EP | claimed |
| US-20080226717-A1 | Sublingual Coated Tablet | ETHYPHARM (FR) | 2008-09-18 | — | — | US | claimed |
| WO-2007141328-A1 | LOW DOSE SUBLINGUAL TABLETS OF OPIOID ANALGESICS AND PREPARATION PROCESS | ETHYPHARM (FR) | 2007-12-13 | — | — | WO | claimed |
| US-20070286900-A1 | LOW DOSE TABLETS OF OPIOID ANALGESICS AND PREPARATION PROCESS | ETHYPHARM (FR) | 2007-12-13 | — | — | US | claimed |
| EP-1858491-A1 | SUBLINGUAL COATED TABLET | ETHYPHARM (FR) | 2007-11-28 | — | — | EP | claimed |
| WO-2006097361-A1 | SUBLINGUAL COATED TABLET | ETHYPHARM (FR) | 2006-09-21 | — | — | WO | claimed |
| WO-2024050072-A2 | RETAINERS FOR INTRAORAL DRUG DELIVERY DEVICES AND METHODS OF USE THEREOF | SYNAGILE CORPORATION (US) | 2024-03-07 | — | — | WO | disclosed |
| US-20230355939-A1 | DEVICES AND METHODS FOR CONTINUOUS EXTRUSION OF A DRUG INTO THE MOUTH | SYNAGILE CORPORATION | 2023-11-09 | — | — | US | disclosed |
| EP-4213761-A1 | DEVICES AND METHODS FOR CONTINUOUS EXTRUSION OF A DRUG INTO THE MOUTH | SynAgile Corporation (US) | 2023-07-26 | — | — | EP | disclosed |
| US-20230181506-A1 | PHARMACEUTICAL SUSPENSIONS CONTAINING DRUG PARTICLES, DEVICES FOR THEIR ADMINISTRATION, AND METHODS OF THEIR USE | SYNAGILE CORPORATION | 2023-06-15 | — | — | US | disclosed |
| CN-114728011-A | Preparations comprising steroid dimers and uses thereof in therapeutic agent delivery | 波纹疗法公司 | 2022-07-08 | — | — | CN | disclosed |
| US-20080226717-A1 | Sublingual Coated Tablet | ETHYPHARM (FR) | 2008-09-18 | — | — | US | disclosed |
| CN-101141951-A | Sublingual coated tablet | ETHYPHARM SA (FR) | 2008-03-12 | — | — | CN | disclosed |
| WO-2007141328-A1 | LOW DOSE SUBLINGUAL TABLETS OF OPIOID ANALGESICS AND PREPARATION PROCESS | ETHYPHARM (FR) | 2007-12-13 | — | — | WO | disclosed |
| US-20070286900-A1 | LOW DOSE TABLETS OF OPIOID ANALGESICS AND PREPARATION PROCESS | ETHYPHARM (FR) | 2007-12-13 | — | — | US | disclosed |
| EP-1858491-A1 | SUBLINGUAL COATED TABLET | ETHYPHARM (FR) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006097361-A1 | SUBLINGUAL COATED TABLET | ETHYPHARM (FR) | 2006-09-21 | — | — | WO | disclosed |