Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CACNA2D1 | P54289 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11470172 | 0.86 | GPR84 (0.40) | LMNAMAPTALDH1A1MEN1HTT | |
| SCHEMBL11484157 | 0.78 | LMNA (0.49) | LMNACACNA2D1MAPTALDH1A1MEN1 | |
| SCHEMBL11469393 | 0.78 | TP53 (0.46) | LMNACACNA2D1MAPTALDH1A1MEN1 | |
| SCHEMBL10943076 | 0.78 | MAPT (0.44) | LMNACACNA2D1MAPTALDH1A1MEN1 | |
| SCHEMBL11467134 | 0.75 | PTGS1 (0.40) | LMNAMAPTALDH1A1HTTNPSR1 | |
| SCHEMBL11477775 | 0.73 | WDR5 (0.36) | LMNAMAPTALDH1A1NPSR1POLB | |
| SCHEMBL11477306 | 0.73 | GPR84 (0.51) | LMNACACNA2D1MAPTALDH1A1MEN1 | |
| SCHEMBL11238972 | 0.73 | GPR84 (0.43) | LMNAMAPTALDH1A1MEN1HTT | |
| SCHEMBL11241755 | 0.73 | CACNA2D1 (0.47) | LMNACACNA2D1MAPTALDH1A1MEN1 | |
| SCHEMBL11484210 | 0.72 | LMNA (0.42) | LMNACACNA2D1MAPTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4190725-A | ANTIINFLAMMATORY | ELI LILLY AND COMPANY (US) | 1980-02-26 | — | — | US | disclosed |
| US-4021553-A | 5,6-Diaryl-1,2,4-triazines as topically-active anti-inflammatory agents | ELI LILLY AND COMPANY (US) | 1977-05-03 | — | — | US | disclosed |