Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CACNA2D1 | P54289 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11477306 | 0.80 | GPR84 (0.51) | LMNACACNA2D1MAPTALDH1A1MEN1 | |
| SCHEMBL11478263 | 0.78 | LMNA (0.46) | LMNACACNA2D1MAPTALDH1A1MEN1 | |
| SCHEMBL11241755 | 0.77 | CACNA2D1 (0.47) | LMNACACNA2D1MAPTALDH1A1MEN1 | |
| SCHEMBL11472297 | 0.76 | LMNA (0.58) | LMNACACNA2D1MAPTALDH1A1MEN1 | |
| SCHEMBL11470583 | 0.76 | GPR84 (0.65) | LMNACACNA2D1MAPTALDH1A1MEN1 | |
| SCHEMBL11471160 | 0.75 | LMNA (0.51) | LMNACACNA2D1MAPTALDH1A1MEN1 | |
| SCHEMBL11485851 | 0.74 | TP53 (0.54) | CACNA2D1MAPTALDH1A1MEN1HTT | |
| SCHEMBL11484210 | 0.72 | LMNA (0.42) | LMNACACNA2D1MAPTALDH1A1MEN1 | |
| SCHEMBL10749961 | 0.72 | HRH3 (0.52) | LMNACACNA2D1MAPTALDH1A1MEN1 | |
| SCHEMBL11468262 | 0.71 | LMNA (0.47) | LMNACACNA2D1MAPTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4190725-A | ANTIINFLAMMATORY | ELI LILLY AND COMPANY (US) | 1980-02-26 | — | — | US | disclosed |
| US-4021553-A | 5,6-Diaryl-1,2,4-triazines as topically-active anti-inflammatory agents | ELI LILLY AND COMPANY (US) | 1977-05-03 | — | — | US | disclosed |